AAVLP Vaccines

2A Pharma is a clinical stage Swedish/Danish biopharmaceutical company focused on discovering, developing and commercialising novel, cost effective prophylactic and therapeutic vaccines based on our patented AAVLP Platform.

Dosing Completed

All volunteers have now received three doses of 2AP01 (AAVLP-HPV), our very broad spectrum HPV vaccine formulated without adjuvant. The

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Article in MedWatch

Article about 2A Pharma in the Danish pharma/biotech media MedWatch (behind paywall): Danish: https://medwatch.dk/secure/Medicinal___Biotek/article11272123.ece English: https://medwatch.dk/secure/Top_picks_in_english/article11274345.ece

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About Us

The story of the technology behind our company started in 2005 when John Nieland, then Head of Immunology at Medigene AG, and colleagues Markus Hörer and Hildegard Büning discovered how to replace the peptides on the surface of a modified adeno virus with antigens to induce and enhance the specific antibody immune response. The AAVLP inventions were patented in the following years, but the potential was never commercialised as Medigene focused on other projects and John Nieland left the company to pursue new opportunities.

In 2014 John Nieland joined Professor Søren Nielsen at Aalborg University and the idea to develop a company around AAVLP was again ignited. John Nieland and Søren Nielsen approached Medigene with their idea and started the discussions about an in-licensing agreement while also exploring funding options. During this process, the team was expanded to include Preben Bruun-Nyzell. 2A Pharma AB was founded on 12 December 2016 in Malmö, Sweden. Shortly thereafter, the company’s first employee, Jeanette Prangsgaard, joined as Project Manager for our lead project.


We have chosen to develop a range of vaccines to showcase the potential of our AAVLP platform.

Our lead vaccine candidate, a broad coverage prophylactic HPV vaccine formulated without adjuvants, is at the clinical stage (first volunteer dosed 2 March 2019). We have six additional projects at pre-clinical proof-of-principle stage and several R&D projects underway.

We have achieved this strong pipeline by a combination of internal development work and collaboration with academic and non-academic partners.

We are interested in additional partnerships to further develop the existing pipeline or new vaccines of mutual interest.

The 2A Pharma Team

Preben Bruun-Nyzell


John Nieland


Jeanette Prangsgaard

Project Manager

Mathilde Sanden

Project Manager

Board of directors

Peter Lainevool, Chairman

CEO S.A.B. Corporate Finance

Søren Nielsen, MD


Preben Bruun-Nyzell

CEO 2A Pharma

John Nieland

COO 2A Pharma