Søren Nielsen, MD, dr.med.
CEO

Email: sn@2apharma.com

Søren Nielsen has held full professorships at Faculty of Health Sciences at Aarhus University and at Aalborg University since 1997. He is one of the world’s leading scientists in the field of cellular/molecular biology, physiological and pathological studies of aquaporins, sodium channels and transporters with more than 380 articles published. He brings to 2A Pharma also invaluable business knowledge through his experience with Action Pharma where he was co-founder and Executive (CEO 2001-2010, COO 2010-2012) and raised EUR 30 million to conduct clinical trials (Phase 2a & 2b) with AP214 – a candidate for acute renal failure – in Europe and the United States. AP214 was acquired in May 2012 by Abbott, Chicago (~ $ 110 million). For his research, he has received several awards, including the Novo Nordisk Prize, the Novo Nordisk Foundation 2009.

Publications

Pituitary gonadotropins, prolactin and growth hormone differentially regulate AQP1 expression in the porcine ovarian follicular cells.

Skowronski, Mariusz T.; Mlotkowska, Patrycja; Tanski, Damian; Lepiarczyk, Ewa; Oklinski, Michal K.; Nielsen, Søren; Skowronska, Agnieszka.
International Journal of Molecular Sciences, Vol. 19, No. 1, 5, 2018.

Blocking of carnitine palmitoyl transferase 1 potently reduces stress-induced depression in rat highlighting a pivotal role of lipid metabolism.

Mørkholt, Anne Skøttrup; Wiborg, Ove; Nieland, Jette G. K.; Nielsen, Søren; Nieland, John Dirk.
Scientific Reports, Vol. 7, 2158, 19.05.2017.

Characterization of human autoantibody response to brain proteins in multiple sclerosis patients.

Mørkholt, Anne Skøttrup; Kastaniegaard, Kenneth; Stensballe, Allan; Nielsen, Søren; Nieland, John Dirk.
International Journal of MS Care, Vol. 19, No. Suppl. 1, (NP02), 2017, p. 54.

Comparison of Etomoxir, a lipid metabolism blocker, and interferon-beta treatment on antibody recognition of brain proteins in Multiple Sclerosis.

Mørkholt, Anne Skøttrup; Kastaniegaard, Kenneth; Trabjerg, Michael Sloth; Gopalasingam, Gopana; Niganze, Wanda; Oklinski, Michal Krystian; Larsen, Agnete; Nieland, Jette G. K.; Stensballe, Allan; Nielsen, Søren; Nieland, John Dirk; Mørkholt, Anne Skøttrup.
2017. Abstract from Annual Meeting of the Consortium of Multiple Sclerosis Centers, CMSC, New Orleans, LA, United States.

Comparison of etomoxir, a lipid metabolism blocker, and interferon beta treatment on antibody recognition of brain proteins in multiple sclerosis.

Mørkholt, Anne Skøttrup; Kastaniegaard, Kenneth; Trabjerg, Michael Sloth; Gopalasingam, Gopana; Niganze, Wanda; Oklinski, Michal Krystian; Larsen, Agnete; Nieland, Jette G. K.; Stensballe, Allan; Nielsen, Søren; Nieland, John Dirk.
International Journal of MS Care, Vol. 19, No. Suppl. 1, (NP01), 2017, p. 54.

Comparison of Etomoxir, a lipid metabolism blocker, and interferon-β treatment on antibody recognition of brain proteins in Multiple Sclerosis.

Mørkholt, Anne Skøttrup; Kastaniegaard, Kenneth; Trabjerg, Michael Sloth; Niganze, Wanda; Gopalasingam, Gopana; Larsen, Agnete; Stensballe, Allan; Nielsen, Søren; Nieland, John Dirk.
2017. Poster presented at Annual Meeting of the Consortium of Multiple Sclerosis Centers, CMSC, New Orleans, LA, United States.

Modifications like citrulination and MDA adducts, lipidation, and the immune system: A menage à trois gone wrong in multiple sclerosis.

Kastaniegaard, Kenneth; Nieland, John Dirk; Mørkholt, Anne Skøttrup; Stensballe, Allan; Nielsen, Søren.
International Journal of MS Care, Vol. 19, No. Suppl. 1, NP05, 2017, p. 55-56.

Role of Renal Compensation and dDAVP in a Mouse Model of Hyponatremia and Brain Edema induced by Water Intoxication.

Bordoni, Luca; Ramirez Jimenez, Edgar; Nielsen, Søren; Østergaard, Leif; Frische, Sebastian.
F A S E B Journal, Vol. 31, No. 1 Suppl., 1027.7, 04.2017.

Temporal deletion of Aqp11 in mice is linked to the severity of cyst-like disease.

Rützler, Michael; Rojek, Aleksandra; Damgaard, Mads Vammen; Andreasen, Arne; Fenton, Robert A.; Nielsen, Søren.
American Journal of Physiology: Renal Physiology, Vol. 312, No. 2, 2017, p. F343-F351.

The effect of CPT1a inhibition in ischemic CNS injury: Studies in a murine model of permanent middle cerebral artery occlusion (MCAO).

Poulsen, Kristoffer Bødkergaard; Flaeng, S. B.; Lambertsen, K. L.; Nieland, John Dirk; Nielsen, Søren; Larsen, A.
Kongres for Medicinsk Studenterforskning, Abstracts, 16.-19. marts 2017, Nyborg, Danmark. Selskab for Medicinsk Studenterforskning, 2017. p. 66.

Whole-body acid-base modeling revisited.

Ring, Troels; Nielsen, Søren.
American Journal of Physiology: Renal Physiology, Vol. 312, No. 4, 2017, p. F647-F653.

Aquaporin-9 facilitates membrane transport of hydrogen peroxide in mammalian cells.

Watanabe, Sachiko; Moniaga, Catharina Sagita; Nielsen, Søren; Hara-Chikuma, Mariko.

Biochemical and Biophysical Research Communications, Vol. 471, No. 1, 2016, p. 191-197.

Aquaporins in health and disease: new molecular targets for drug discovery.

Soveral, Graca (Editor); Nielsen, Søren (Editor); Casini, Angela (Editor).
CRC Press, 2016.

Aquaporins in the spinal cord.

Oklinski, Michael Krystian; Skowronski, Mariusz T.; Skowronska, Agnieszka; Rützler, Michael; Jensen, Kirsten Nørgaard; Nieland, John D.; Kwon, Tae-Hwan; Nielsen, Søren.
International Journal of Molecular Sciences, Vol. 17, No. 12, 2050, 2016.

Assessing the Role of Citrullination and Lipid Interaction with Myelin Basic Protein in Multiple Sclerosis Etiology.

Kastaniegaard, Kenneth; Bennike, Tue Bjerg; Nielsen, Søren; Stensballe, Allan; Nieland, John Dirk.
2016. Abstract from Consortium of Multiple Sclerosis Centers (CMSC) 2016 Annual Meeting, National Harbor, MD, United States.

A systematic characterization of aquaporin-9 expression in human normal and pathological tissues.

Lindskog, Cecilia; Asplund, Anna; Catrina, Anca; Nielsen, Søren; Rützler, Michael.
Journal of Histochemistry and Cytochemistry, Vol. 64, No. 5, 2016, p. 287-300.

Blocking the Lipid Metabolism as a New Treatment Strategy for Multiple Sclerosis.
Mørkholt, Anne Skøttrup; Nielsen, Søren; Nieland, John Dirk.

Abstract from Annual Meeting of the Consortium of Multiple Sclerosis Centers, CMSC, National Harbor, MD, United States.

Blocking the lipid metabolism as a new treatment strategy for multiple sclerosis.

Mørkholt, Anne Skøttrup; Larsen, Agnete; Nieland, Jette G. K.; Issazadeh, Shohreh; Nielsen, Søren; Nieland, John Dirk.
2016. Poster presented at Annual Meeting of the Consortium of Multiple Sclerosis Centers, CMSC, National Harbor, MD, United States.

Expression of aquaporin 1 and 5 and their regulation by ovarian hormones, arachidonic acid, forskolin and cAMP during implantation in pigs.

Skowronska, A.; Mlotkowska, P.; Majewski, M.; Nielsen, Søren; Skowronski, M. T.
Physiological Research, Vol. 65, No. 4, 2016, p. 637-650.

Highly effective treatment of multiple sclerosis by blocking the lipid metabolism.

Mørkholt, Anne Skøttrup; Larsen, Agnete; Issazadeh, Shohreh; Nieland, Jette G. K.; Nielsen, Søren; Nieland, John Dirk.
2016. Abstract from 32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis, ECTRIMS, London, United Kingdom.

Maximal oxygen consumption is reduced in aquaporin-1 knockout mice.

Al-Samir, Samer; Goossens, Dominique; Cartron, Jean-Pierre; Nielsen, Søren; Scherbarth, Frank; Steinlechner, Stephan; Gros, Gerolf; Endeward, Volker.
Frontiers in Physiology, Vol. 7, 347, 2016.

Modulatory effects of steroid hormones, oxytocin, arachidonic acid, forskolin and cyclic AMP on the expression of aquaporin 1 and aquaporin 5 in the porcine uterus during placentation.

Skowronska, A.; Mlotkowska, P.; Okrasa, S.; Nielsen, Søren; Skowronski, M. T.
Journal of Physiology and Pharmacology, Vol. 67, No. 2, 2016, p. 311-319.

Preface.

Nielsen, Søren; Agre, Peter.
Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery. ed.
Graca Soveral; Søren Nielsen; Angela Casini. CRC Press, 2016. p. vii-viii.

Prolonged starvation causes up-regulation of AQP1 in adipose tissue capillaries of AQP7 knock-out mice.

Skowronski, Mariusz T.; Skowronska, Agnieszka; Rojek, Aleksandra; Oklinski, Michael Krystian; Nielsen, Søren.
International Journal of Molecular Sciences, Vol. 17, No. 7, 1101, 2016.

Proteomics-driven design of endothelial stress-based protein array for disease prognostics: applied to plasma and cerebrospinal fluid.

Kastaniegaard, Kenneth; Jørgensen, Malene Møller; Bæk, Rikke ; Sejrbæk, Tobias; Wiwie, C.; Baumbach, J.; Zachar, Vladimir; Moos, Torben; Nielsen, Søren; Nieland, John Dirk; Cotton, F.; Guttmann, C.; Illes, Z.; Stensballe, Allan.
Journal of Extracellular Vesicles, Vol. 5, No. Suppl. 1, OW2.2, 2016, p. 4.

Renal aquaporins: role in water balance disorders.

Kwon, Tae-Hwan; Nielsen, Søren.
Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery. ed.
Graca Soveral; Søren Nielsen; Angela Casini. CRC Press, 2016. p. 125-155.

Activation of muscarinic receptors in rat parotid acinar cells induces AQP5 trafficking to nuclei and apical plasma membrane.

Cho, Gota; Bragiel, Aneta M.; Wang, Di; Pieczonka, Tomasz D.; Skowronski, Mariusz T.; Shono, Masayuki; Nielsen, Søren; Ishikawa, Yasuko.
BBA Gene Regulatory Mechanisms, Vol. 1850, No. 4, 2015, p. 784-793.

Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity.

Moniaga, Catharina Sagita; Watanabe, Sachiko; Honda, Tetsuya; Nielsen, Søren; Hara-Chikuma, Mariko.
Scientific Reports, Vol. 5, 15319, 2015.

AVP-induced increase in AQP2 and p-AQP2 is blunted in heart failure during cardiac remodeling and is associated with decreased AT1R abundance in rat kidney.

Lütken, Sophie Constantin; Frøkiær, Jørgen; Nielsen, Søren.
PLoS ONE, Vol. 10, No. 2, 0116501, 2015.

Clustering of Kir4.1 at specialized compartments of the lateral membrane in ependymal cells of rat brain.

Fujita, Akikazu; Inanobe, Atsushi; Hibino, Hiroshi; Nielsen, Søren; Ottersen, Ole Petter; Kurachi, Yoshihisa.
Cell and Tissue Research, Vol. 359, No. 2, 02.2015, p. 627-34.

CPT1a mutation leads the way for new medication for the treatment of multiple sclerosis.

Nieland, John Dirk; Nieland, Jette G. K.; Mørkholt, Anne Skøttrup; Bolther, Luise; Nielsen, Søren.
Multiple Sclerosis Journal, Vol. 21, No. 11 (Suppl.), 2015, p. 786-787, No. P1497.

Deletion of aquaporin 11 in transgenic mice prior to post-natal day 12 results in proximal tubule injury and cyst formation.

Nielsen, Søren; Damgaard, Mads Vammen; Rützler, Michael; Fenton, Robert A.; Rojek, Aleksandra M.
Journal of the American Society of Nephrology, Vol. 26, No. Abstract Suppl., 2015, p. 380A, No. FR-PO103.

Deletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice.

Spegel, Peter; Chawade, Aakash; Nielsen, Søren; Kjellbom, Per; Rützler, Michael.
Physiological Reports, Vol. 3, No. 9, e12538, 2015.

Difference in expression between AQP1 and AQP5 in porcine endometrium and myometrium in response to steroid hormones, oxytocin, arachidonic acid, forskolin and cAMP during the mid-luteal phase of the estrous cycle and luteolysis.

Skowronska, Agnieszka; Mlotkowska, Patrycja; Nielsen, Søren; Skowronski, Mariusz T.

Reproductive Biology and Endocrinology, Vol. 13, No. 1, 131, 2015.

Dynamic subcellular localization of aquaporin-7 in white adipocytes.

Miyauchi, Takayuki; Yamamoto, Hiroyuki; Abe, Yoichiro; Yoshida, Go J; Rojek, Aleksandra; Sohara, Eisei; Uchida, Shinichi; Nielsen, Søren; Yasui, Masato.
FEBS Letters, Vol. 589, No. 5, 2015, p. 608-614.

Expression of aquaporin 1, 5 and 9 in the ovarian follicles of cycling and early pregnant pigs.

Skowronska, A.; Mlotkowska, P.; Eliszewski, M.; Nielsen, Søren; Skowronski, M. T.
Physiological Research, Vol. 64, No. 2, 2015, p. 237-245.


Hepatic AQP9 expression in male rats is reduced in response to PPARα agonist treatment.

Lebeck, Janne; Cheema, Muhammad Umar; Skowronski, Mariusz T.; Nielsen, Søren; Prætorius, Jeppe.
American Journal of Physiology: Renal Physiology, Vol. 308, No. 3, 2015, p. G198-G205.

Immunolocalization of AQP5 in resting and stimulated normal labial glands and in Sjögren’s syndrome.

Gresz, V; Horvath, A; Gera, I; Nielsen, Søren; Zelles, T.
Oral Oncology, Vol. 21, No. 1, 01.2015, p. e114-20.

Molecular physiology of water balance.

Knepper, Mark A.; Kwon, Tae-Hwan; Nielsen, Søren.
The New England Journal of Medicine, Vol. 372, No. 14, 2015, p. 1349-1358.

Progesterone, estradiol, arachidonic acid, oxytocin, forskolin and cAMP influence on aquaporin 1 and 5 expression in porcine uterine explants during the mid-luteal phase of the estrous cycle and luteolysis: an in vitro study.

Skowronska, Agnieszka; Mlotkowska, Patrycja; Wojciechowicz, Bartosz; Okrasa, Stanislaw; Nielsen, Søren; Skowronski, Mariusz T.
Reproductive Biology and Endocrinology, Vol. 13, 7, 2015.

Tankyrase-mediated β-catenin activity regulates vasopressin-induced AQP2 expression in kidney collecting duct mpkCCDc14 cells.

Jung, Hyun Jun; Kim, Sang-Yeob; Choi, Hyo-Jung; Park, Eui-Jung; Lim, Jung-Suk; Frøkiaer, Jørgen; Nielsen, Søren; Kwon, Tae-Hwan.
American Journal of Physiology: Renal Physiology, Vol. 308, No. 5, 2015, p. F473-F486.

Acute kidney injury in rats with or without pre-existing chronic kidney disease: cytokine/chemokine response.

Skott, Martin; Nørregaard, Rikke; Birke-Sørensen, Hanne; Palmfeldt, Johan; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Nielsen, Søren.
Nephrology (Carlton, Vic.), Vol. 19, No. 7, 07.2014, p. 410-9.

Altered aquaporin expression in glaucoma eyes.

Tran, Thuy Linh; Bek, Toke; la Cour, Morten; Nielsen, Søren; Prause, Jan Ulrik; Hamann, Steffen; Heegaard, Steffen.
APMIS – Journal of Pathology, Microbiology and Immunology, Vol. 122, No. 9, 09.2014, p. 772-80.

Early targets of lithium in rat kidney inner medullary collecting duct include p38 and ERK1/2.

Trepiccione, Francesco; Pisitkun, Trairak; Hoffert, Jason D; Poulsen, Søren B; Capasso, Giovambattista; Nielsen, Søren; Knepper, Mark A; Fenton, Robert A; Christensen, Birgitte M.
Kidney International, Vol. 86, No. 4, 2014, p. 757-67.

Prevention of kidney injury or disease.

Nielsen, Søren (Inventor); Jonassen, Thomas Engelbrecht Nordkild (Inventor); Khan, Samina (Inventor); Houser, Mark T. (Inventor); Lumholtz, Ib Bo (Inventor); Beckert, Michael (Inventor); Beaver, Thomas (Inventor).
Patent No.: WO/2014/058786. Apr 17, 2014.

The physiological and pathophysiological functions of renal and extrarenal vasopressin V2 receptors.

Juul, Kristian Vinter; Bichet, Daniel G; Nielsen, Søren; Nørgaard, Jens Peter.
A J P: Renal Physiology (Online), Vol. 306, No. 9, 2014, p. F931-40.

α-Melanocyte stimulating hormone treatment in pigs does not improve early graft function in kidney transplants from brain dead donors.

van Rijt, WG; Secher, N.; Keller, AK; Møldrup, U; Chynau, Y; Ploeg, J; van Goor, H; Nørregaard, R; Birn, H.; Frøkiaer, J; Nielsen, Søren; Leuvenink, HG; Jespersen, B.
PLoS ONE, Vol. 9, No. 4, 2014.

AQP9 expression in glioblastoma multiforme tumors is limited to a small population of astrocytic cells and CD15(+)/CalB(+) leukocytes.

Jelen, Sabina; Parm Ulhøi, Benedicte; Larsen, Agnete; Frøkiær, Jørgen; Nielsen, Søren; Rützler, Michael.
PLOS ONE, Vol. 8, No. 9, 2013, p. e75764.

Aquaporins 6-12 in the human eye.

Tran, Thuy Linh; Bek, Toke; Holm, Lars; la Cour, Morten; Nielsen, Søren; Prause, Jan Ulrik; Rojek, Aleksandra; Hamann, Steffen; Heegaard, Steffen.
Acta Ophthamologica (Online), Vol. 91, No. 6, 09.2013, p. 557-63.

Congestive heart failure in rats is associated with increased collecting duct vasopressin sensitivity and vasopressin type 2 receptor reexternalization.

Brønd, Lone; Müllertz, Katrine M; Torp, Malene; Nielsen, Jonas; Graebe, Martin; Hadrup, Niels; Nielsen, Søren; Christensen, Sten; Jonassen, Thomas E N.
A J P: Renal Physiology (Online), Vol. 305, No. 11, 01.12.2013, p. F1547-54.

Effect of volume expansion with hypertonic- and isotonic saline and isotonic glucose on sodium and water transport in the principal cells in the kidney.

Jensen, Janni M; Mose, Frank H; Bech, Jesper N; Nielsen, Søren; Pedersen, Erling B.
B M C Nephrology, Vol. 14, 2013, p. 202.

Evaluation of cellular plasticity in the collecting duct during recovery from lithium-induced nephrogenic diabetes insipidus.

Trepiccione, Francesco; Capasso, Giovambattista; Nielsen, Søren; Christensen, Birgitte Mønster.
A J P: Renal Physiology (Online), Vol. 305, No. 6, 15.09.2013, p. F919-29.

Liver-specific Aquaporin 11 knockout mice show rapid vacuolization of the rough endoplasmic reticulum in periportal hepatocytes after amino acid feeding.

Rojek, Aleksandra; Füchtbauer, Ernst-Martin; Füchtbauer, Annette; Jelen, Sabina; Malmendal, Anders; Fenton, Robert A; Nielsen, Søren.
American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 304, No. 5, 01.03.2013, p. G501-15.

Long-term vasopressin-V2-receptor stimulation induces regulation of aquaporin 4 protein in renal inner medulla and cortex of Brattleboro rats.

Poulsen, Søren Brandt; Kim, Young-Hee; Frøkiær, Jørgen; Nielsen, Søren; Christensen, Birgitte Mønster.
Nephrology, Dialysis, Transplantation, Vol. 28, No. 8, 08.2013, p. 2058-65.

Method for preventing or reducing acute renal failure by administration of therapeutically active α-MSH analogues.

Jonassen, Thomas Engelbrecht Nordkild (Inventor); Nielsen, Søren (Inventor); Frøkiær, Jørgen (Inventor); Larsen, Bjarne Due (Inventor).
Patent No.: US20130217628. Aug 22, 2013.

The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site.

Wacker, Sören J; Aponte-Santamaría, Camilo; Kjellbom, Per; Nielsen, Søren; de Groot, Bert L; Rützler, Michael.

Journal of Membrane Biology, Vol. 30, No. 3, 2013, p. 246-60.

Age-related changes in expression in renal AQPs in response to congenital, partial, unilateral ureteral obstruction in rats.

Wang, Guixian; Yuan, Weitang; Kwon, Tae-Hwan; Li, Zhenzhen; Wen, Jianguo; Topcu, Sukru Oguzkan; Djurhuus, Jens Christian; Nielsen, Søren; Frøkiær, Jørgen.
Pediatric Nephrology, Vol. 27, No. 1, 01.2012, p. 83-94.

Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes.

Jelen, Sabina; Gena, Patrizia; Lebeck, Janne; Rojek, Aleksandra; Praetorius, Jeppe; Frøkiaer, Jørgen; Fenton, Robert A; Nielsen, Søren; Calamita, Giuseppe; Rützler, Michael.
American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 303, No. 11, 01.12.2012, p. G1279-87.

Biophysical assessment of aquaporin-9 as principal facilitative pathway in mouse liver import of glucogenetic glycerol.

Calamita, Giuseppe; Gena, Patrizia; Ferri, Domenico; Rosito, Anna; Rojek, Aleksandra; Nielsen, Søren; Marinelli, Raúl A; Frühbeck, Gema; Svelto, Maria.
Molecular and Cellular Biology, Vol. 104, No. 6, 06.2012, p. 342-51.

Decreased redox-sensitive erythrocyte cation channel activity in aquaporin 9-deficient mice.

Kucherenko, Yuliya V; Huber, Stephan M; Nielsen, Søren; Lang, Florian.
Journal of Membrane Biology, Vol. 245, No. 12, 12.2012, p. 797-805.

Effect of amiloride and spironolactone on renal tubular function, ambulatory blood pressure, and pulse wave velocity in healthy participants in a double-blinded, randomized, placebo-controlled, crossover trial.

Matthesen, Solveig Klok; Larsen, T.; Lauridsen, Thomas Guldager; Vase, Henrik; Gjørup, Pia Holland; Nykjær, Karen Marie; Nielsen, Søren; Pedersen, Erling Bjerregaard.
Clinical and experimental hypertension (New York, N.Y.: 1993), Vol. 34, No. 8, 2012, p. 588-600.

Effects of renal denervation on the NKCC2 cotransporter in the thick ascending limb of the loop of Henle in rats with congestive heart failure.

Torp, M; Brønd, L; Nielsen, J B; Nielsen, Søren; Christensen, S; Jonassen, T E N.
Acta Physiologica (Print), Vol. 204, No. 3, 03.2012, p. 451-9.

Gender-specific effect of physical training on AQP7 protein expression in human adipose tissue.

Lebeck, Janne; Østergård, Torben; Rojek, Aleksandra; Füchtbauer, Ernst-Martin; Lund, Sten; Nielsen, Søren; Praetorius, Jeppe.
Acta Diabetologica, Vol. 49 Suppl 1, 12.2012, p. S215-26.

Anatomy of the Kidney.

Nielsen, Søren.
The Kidney. ed.
BM Brenner. 9th edition. ed. Elsevier, 2011. p. 31-93.

Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice.

Jelen, Sabina; Wacker, Sören; Aponte-Santamaría, Camilo; Skott, Martin; Rojek, Aleksandra; Johanson, Urban; Kjellbom, Per; Nielsen, Søren; de Groot, Bert L; Rützler, Michael.

Journal of Biological Chemistry, Vol. 286, No. 52, 30.12.2011, p. 44319-25.

Cisplatin decreases renal cyclooxygenase-2 expression and activity in rats.

Tusgaard, B; Nørregaard, R; Jensen, A M; Wang, G; Topcu, S O; Wang, Y; Nielsen, Søren; Frøkiaer, J.
Acta Physiologica (Print), Vol. 202, No. 1, 2011, p. 79-90.

Downregulation of aquaporin-1 in alveolar microvessels in lungs adapted to chronic heart failure.

Müllertz, Katrine M; Strøm, Claes; Trautner, Simon; Amtorp, Ole; Nielsen, Søren; Christensen, Sten; Haunsø, Stig; Jonassen, Thomas E N.
Lung, Vol. 189, No. 2, 04.2011, p. 157-66.

E3 ubiquitin-protein ligases in rat kidney collecting duct: response to vasopressin stimulation and withdrawal.

Lee, Yu-Jung; Lee, Jeong-Eun; Choi, Hyo-Jung; Lim, Jung-Suk; Jung, Hyun Jun; Baek, Moon-Chang; Frøkiær, Jørgen; Nielsen, Søren; Kwon, Tae-Hwan.
A J P: Renal Physiology (Online), Vol. 301, No. 4, 2011, p. F883-96.

Fluctuation of aquaporin 1, 5, and 9 expression in the pig oviduct during the estrous cycle and early pregnancy.

Skowronski, Mariusz T; Skowronska, Agnieszka; Nielsen, Soren.
The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society, Vol. 59, No. 4, 04.2011, p. 419-27.

The melanocortin agonist AP214 exerts anti-inflammatory and proresolving properties.

Montero-Melendez, Trinidad; Patel, Hetal B; Seed, Michael; Nielsen, Søren; Jonassen, Thomas E N; Perretti, Mauro.
American Journal of Pathology, Vol. 179, No. 1, 07.2011, p. 259-69.

The α-MSH analogue AP214 attenuates rise in pulmonary pressure and fall in ejection fraction in lipopolysaccharide-induced systemic inflammatory response syndrome in pigs.

Kristensen, Jens; Jonassen, Thomas E N; Rehling, Michael; Tønnesen, Else; Sloth, Erik; Nielsen, Søren; Frøkiaer, Jørgen.
Clinical Physiology and Functional Imaging, Vol. 31, No. 1, 01.2011, p. 54-60.

Alpha-melanocyte stimulating hormone analogue AP214 protects against ischemia induced acute kidney injury in a porcine surgical model.

Simmons, Matthew N; Subramanian, Vairavan; Crouzet, Sebastien; Haber, Georges-Pascal; Colombo, Jose R; Ukimura, Osamu; Nielsen, Søren; Gill, Inderbir S.
Journal of Urology, Vol. 183, No. 4, 04.2010, p. 1625-9.

Antenatal Corticosteroids and Postnatal Fluid Restriction Produce Differential Effects on AQP3 Expression, Water Handling, and Barrier Function in Perinatal Rat Epidermis.

Agren, Johan; Zelenin, Sergey; Svensson, Lill-Britt; Nejsum, Lene N; Nielsen, Soren; Aperia, Anita; Sedin, Gunnar.
Dermatology Research and Practice, Vol. 2010, 2010, p. 789729.

A plate reader-based method for cell water permeability measurement.

Fenton, R A; Moeller, H B; Nielsen, Søren; de Groot, B L; Rützler, M.
A J P: Renal Physiology (Online), Vol. 298, No. 1, 01.2010, p. F224-30.

Cyclooxygenase 2 inhibition exacerbates AQP2 and pAQP2 downregulation independently of V2 receptor abundance in the postobstructed kidney.

Jensen, Anja M; Bae, Eun Hui; Nørregaard, Rikke; Wang, Guixian; Nielsen, Søren; Schweer, Horst; Kim, Soo Wan; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 298, No. 4, 04.2010, p. F941-50.

Degradation of hydroxyapatite in vivo and in vitro requires osteoclastic sodium-bicarbonate co-transporter NBCn1.

Riihonen, Riikka; Nielsen, Søren; Väänänen, H Kalervo; Laitala-Leinonen, Tiina; Kwon, Tae-Hwan.
Matrix Biology, Vol. 29, No. 4, 2010, p. 287-94.

Dehydration-induced increase in aquaporin-2 protein abundance is blocked by nonsteroidal anti-inflammatory drugs.

Baggaley, Erin; Nielsen, Søren; Marples, David.
A J P: Renal Physiology (Online), Vol. 298, No. 4, 04.2010, p. F1051-8.

Direct effect of methylprednisolone on renal sodium and water transport via the principal cells in the kidney.

Lauridsen, Thomas G; Vase, Henrik; Bech, Jesper N; Nielsen, Søren; Pedersen, Erling B.
European Journal of Endocrinology, Vol. 162, No. 5, 2010, p. 961-9.

Increased renal sodium absorption by inhibition of prostaglandin synthesis during fasting in healthy man. A possible role of the epithelial sodium channels.

Lauridsen, Thomas G; Vase, Henrik; Starklint, Jørn; Graffe, Carolina C; Bech, Jesper N; Nielsen, Søren; Pedersen, Erling B.
B M C Nephrology, Vol. 11, 2010, p. 28.

Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation.

Josephsen, Kaj; Takano, Yoshiro; Frische, Sebastian; Praetorius, Jeppe; Nielsen, Søren; Aoba, Takaaki; Fejerskov, Ole.
American Journal of Physiology: Cell Physiology, Vol. 299, No. 6, 12.2010, p. C1299-307.

Neuronal precursor cell proliferation in the hippocampus after transient cerebral ischemia: a comparative study of two rat strains using stereological tools.

Kelsen, Jesper; Larsen, Marianne H; Sørensen, Jens Christian; Møller, Arne; Frøkiaer, Jørgen; Nielsen, Søren; Nyengaard, Jens R; Mikkelsen, Jens D; Rønn, Lars Christian B.
Experimental & Translational Stroke Medicine, Vol. 2, 2010, p. 8.

Pre-existing renal failure worsens the outcome after intestinal ischaemia and reperfusion in rats.

Skott, Martin; Nørregaard, Rikke; Sorensen, Hanne Birke; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Nielsen, Søren.
Nephrology, Dialysis, Transplantation, Vol. 25, No. 11, 11.2010, p. 3509-17.

Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue.

Nørregaard, Rikke; Jensen, Boye L; Topcu, Sukru Oguzkan; Wang, Guixian; Schweer, Horst; Nielsen, Søren; Frøkiaer, Jørgen.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 298, No. 4, 04.2010, p. R1017-25.

Age-dependent renal expression of acid-base transporters in neonatal ureter obstruction.

Wang, Guixian; Topçu, Sükrü Oguzkan; Ring, Troels; Wen, Jianguo; Djurhuus, Jens Christian; Kwon, Tae-Hwan; Nielsen, Søren; Frøkiaer, Jørgen.
Pediatric Nephrology, Vol. 24, No. 8, 2009, p. 1487-500.

Analysis of mice with targeted deletion of AQP9 gene provides conclusive evidence for expression of AQP9 in neurons.

Mylonakou, Maria N; Petersen, Petur H; Rinvik, Eric; Rojek, Aleksandra; Valdimarsdottir, Erla; Zelenin, Sergey; Zeuthen, Thomas; Nielsen, Søren; Ottersen, Ole P; Amiry-Moghaddam, Mahmood.
Neuroscience Research, Vol. 87, No. 6, 2009, p. 1310-22.

Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction.

Jensen, Anja M; Bae, Eun Hui; Fenton, Robert A; Nørregaard, Rikke; Nielsen, Søren; Kim, Soo Wan; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 296, No. 1, 01.2009, p. F127-34.

Aquaporin isoforms involved in physiological volume regulation of murine spermatozoa.

Yeung, Ching-Hei; Callies, Chiara; Rojek, Aleksandra; Nielsen, Søren; Cooper, Trevor G.
Biology of Reproduction, Vol. 80, No. 2, 02.2009, p. 350-7.

Aquaporins in the kidney.

Kwon, Tae-Hwan; Nielsen, Jakob; Møller, Hanne B; Fenton, Robert A; Nielsen, Søren; Frøkiaer, Jørgen.
Handbook of Experimental Pharmacology, Vol. 190, 2009, p. 95-132.

Changes of renal AQP2, ENaC, and NHE3 in experimentally induced heart failure: response to angiotensin II AT1 receptor blockade.

Lütken, Sophie C; Kim, Soo Wan; Jonassen, Thomas; Marples, David; Knepper, Mark A; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 297, No. 6, 12.2009, p. F1678-88.

Effects of thiazide on the expression of TRPV5, calbindin-D28K, and sodium transporters in hypercalciuric rats.

Jang, Hye Ryoun; Kim, Sejoong; Heo, Nam Ju; Lee, Jeong Hwan; Kim, Hyo Sang; Nielsen, Søren; Jeon, Un Sil; Oh, Yun Kyu; Na, Ki Young; Joo, Kwon Wook; Han, Jin Suk.
Journal of the Korean Physical Society, Vol. 24 Suppl, 01.2009, p. S161-9.

Expression of renal aquaporins is down-regulated in children with congenital hydronephrosis.

Wen, Jian Guo; Li, Zhen Zhen; Zhang, Hong; Wang, Yan; Wang, Guixian; Wang, Qingwei; Nielsen, Søren; Djurhuus, Jens Christian; Frøkiaer, Jørgen.
Scandinavian Journal of Urology and Nephrology, Vol. 43, No. 6, 2009, p. 486-93.

Immunolocalization of aquaporin-1, -5, and -7 in the avian testis and vas deferens.

Skowronski, Mariusz T; Leska, Anna; Robak, Anna; Nielsen, Soren.
The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society, Vol. 57, No. 10, 2009, p. 915-22.

Immunolocalization of aquaporin 1, 5, and 9 in the female pig reproductive system.

Skowronski, Mariusz T; Kwon, Tae-Hwan; Nielsen, Søren.
The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society, Vol. 57, No. 1, 01.2009, p. 61-7.

Increased renal adrenomedullin expression in rats with ureteral obstruction.

Nørregaard, Rikke; Bødker, Tina; Jensen, Boye L; Stødkilde, Lene; Nielsen, Søren; Frøkiaer, Jørgen.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 296, No. 1, 01.2009, p. R185-92.

Long-term EGF treatment partially prevents reduction of renal blood flow in response to neonatally induced partial unilateral ureteral obstruction.

Wen, Jian Guo; Wang, Gui Xian; Chen, Yue; Ringgaard, Steffen; Vinter-Jensen, Lars; Jørgensen, Troels Munch; Li, Zhenzhen; Stødkilde-Jørgensen, Hans; Nielsen, Søren; Djurhuus, Jens Christian; Frøkiaer, Jørgen.
Nephron Clinical Practice, Vol. 111, No. 2, 2009, p. e51-9.

Osteoclast differentiation and function in aquaglyceroporin AQP9-null mice.

Liu, Yangjian; Song, Linhua; Wang, Yiding; Rojek, Aleksandra; Nielsen, Søren; Agre, Peter; Carbrey, Jennifer M.
Molecular and Cellular Biology, Vol. 101, No. 3, 03.2009, p. 133-40.

Rapid and segmental specific dysregulation of AQP2, S256-pAQP2 and renal sodium transporters in rats with LPS-induced endotoxaemia.

Olesen, Emma T B; de Seigneux, Sophie; Wang, Guixian; Lütken, Sophie C; Frøkiaer, Jørgen; Kwon, Tae-Hwan; Nielsen, Søren.
Nephrology, Dialysis, Transplantation, Vol. 24, No. 8, 08.2009, p. 2338-49.

Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice.

Carbrey, Jennifer M; Song, Linhua; Zhou, Yao; Yoshinaga, Masafumi; Rojek, Aleksandra; Wang, Yiding; Liu, Yangjian; Lujan, Heidi L; DiCarlo, Stephen E; Nielsen, Søren; Rosen, Barry P; Agre, Peter; Mukhopadhyay, Rita.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 37, 15.09.2009, p. 15956-60.

Targeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in mice.

Josephsen, Kaj; Praetorius, Jeppe; Frische, Sebastian; Gawenis, Lara R; Kwon, Tae-Hwan; Agre, Peter; Nielsen, Søren; Fejerskov, Ole.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 5, 03.02.2009, p. 1638-41.

A current view of the mammalian aquaglyceroporins.

Rojek, Aleksandra; Praetorius, Jeppe; Frøkiaer, Jørgen; Nielsen, Søren; Fenton, Robert A.
Annual Review of Physiology, Vol. 70, 2008, p. 301-27.

Acute regulation of aquaporin-2 phosphorylation at Ser-264 by vasopressin.

Fenton, Robert A; Moeller, Hanne B; Hoffert, Jason D; Yu, Ming-Jiun; Nielsen, Søren; Knepper, Mark A.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 8, 26.02.2008, p. 3134-9.

Aldosterone-mediated apical targeting of ENaC subunits is blunted in rats with streptozotocin-induced diabetes mellitus.

O’Neill, Heidi; Lebeck, Janne; Collins, Patrick B; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Nielsen, Søren.
Nephrology, Dialysis, Transplantation, Vol. 23, No. 5, 2008, p. 1546-55.

A novel method of ligand peptidomics to identify peptide ligands binding to AQP2-expressing plasma membranes and intracellular vesicles of rat kidney.

Lee, Yu-Jung; Choi, Hyo-Jung; Lim, Jung-Suk; Earm, Ji-Hyun; Lee, Byung-Heon; Kim, In-San; Frøkiaer, Jørgen; Nielsen, Søren; Kwon, Tae-Hwan.
A J P: Renal Physiology (Online), Vol. 295, No. 1, 07.2008, p. F300-9.

AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality.

Doi, K; Hu, X; Yuen, P S T; Leelahavanichkul, A; Yasuda, H; Kim, S M; Schnermann, J; Jonassen, T E N; Frøkiaer, J; Nielsen, Søren; Star, R A.
Kidney International, Vol. 73, No. 11, 06.2008, p. 1266-74.

Aquaporin 1 is expressed in the human endometrium during normal cycle and increases after mifepristone treatment.

Hildebrandt, A.; Stavreus-Evers, A.; Latikumar, P.G.; Nielsen, Søren; Mints, M.; Gemzell-Danielsson, K.
International Journal of Molecular Medicine, Vol. 22, No. 1, 2008, p. 49-53.

Dysregulation of renal aquaporins and epithelial sodium channel in lithium-induced nephrogenic diabetes insipidus.

Nielsen, Jakob; Kwon, Tae-Hwan; Christensen, Birgitte Mønster; Frøkiaer, Jørgen; Nielsen, Søren.
Seminars in Nephrology, Vol. 28, No. 3, 2008, p. 227-44.

Effects of alpha-lipoic acid on ischemia-reperfusion-induced renal dysfunction in rats.

Bae, Eun Hui; Lee, Kyun Sang; Lee, Jongun; Ma, Seong Kwon; Kim, Nam Ho; Choi, Ki Chul; Frøkiaer, Jørgen; Nielsen, Søren; Kim, Sun Young; Kim, Sung Zoo; Kim, Suhn Hee; Kim, Soo Wan.
A J P: Renal Physiology (Online), Vol. 294, No. 1, 01.2008, p. F272-80.

Experimental congenital vesicoureteral reflux in sheep is associated with reduced renal expression levels of aquaporin 1 and 2.

Gobet, Rita; Norregaard, Rikke; Cisek, Lars J; Peters, Craig A; Nielsen, Søren; Frøkiaer, Jorgen.
Journal of Urology, Vol. 179, No. 6, 06.2008, p. 2396-401; discussion 2401-2.

NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells.

de Seigneux, Sophie; Leroy, Valérie; Ghzili, Hafida; Rousselot, Martine; Nielsen, Søren; Rossier, Bernard C; Martin, Pierre-Yves; Féraille, Eric.
Journal of Biological Chemistry, Vol. 283, No. 37, 12.09.2008, p. 25671-81.

Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation.

Nielsen, Jakob; Hoffert, Jason D; Knepper, Mark A; Agre, Peter; Nielsen, Søren; Fenton, Robert A.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 9, 04.03.2008, p. 3634-9.

Reduction of ischemic stroke in rat brain by alpha melanocyte stimulating hormone.

Chen, Gang; Frøkiaer, Jørgen; Pedersen, Michael; Nielsen, Søren; Si, Zhichao; Pang, Qi; Stødkilde-Jørgensen, Hans.
Neuropeptides, Vol. 42, No. 3, 06.2008, p. 331-8.

Regulation of AQP4 protein expression in rat brain astrocytes: role of P2X7 receptor activation.

Lee, MoonHee; Lee, Sung-Jin; Choi, Hyo-Jung; Jung, Yong-Wook; Frøkiaer, Jørgen; Nielsen, Søren; Kwon, Tae-Hwan.
Brain Research, Vol. 1195, 21.02.2008, p. 1-11.

Ureter obstruction alters expression of renal acid-base transport proteins in rat kidney.

Wang, Guixian; Li, Chunling; Kim, SW; Ring, Troels; Wen, J; Djurhuus, Jens Christian; Wang, W; Nielsen, Søren; Frøkiær, Jørgen.
American Journal of Physiology: Renal Physiology, Vol. 295, No. 2, 2008, p. 497-506.
2007

Acute growth hormone administration induces antidiuretic and antinatriuretic effects and increases phosphorylation of NKCC2.

Dimke, Henrik; Flyvbjerg, Allan; Bourgeois, Soline; Thomsen, Klaus; Frøkiaer, Jørgen; Houillier, Pascal; Nielsen, Søren; Frische, Sebastian.
A J P: Renal Physiology (Online), Vol. 292, No. 2, 02.2007, p. F723-35.

Altered expression of epithelial sodium channel in rats with bilateral or unilateral ureteral obstruction.

Li, Chunling; Wang, Weidong; Norregaard, Rikke; Knepper, Mark A; Nielsen, Søren; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 293, No. 1, 07.2007, p. F333-41.

AQP7 is localized in capillaries of adipose tissue, cardiac and striated muscle: implications in glycerol metabolism.

Skowronski, Mariusz T; Lebeck, Janne; Rojek, Aleksandra; Praetorius, Jeppe; Füchtbauer, Ernst-Martin; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 292, No. 3, 03.2007, p. F956-65.

Aquaporin 4 regulation during acute and long-term experimental Herpes simplex virus encephalitis.

Martinez Torres, F J; Völcker, D; Dörner, N; Lenhard, Th; Nielsen, Søren; Haas, J; Kiening, K; Meyding-Lamadé, U.
Journal of NeuroVirology, Vol. 13, No. 1, 2007, p. 38-46.

Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence.

Liu, Yangjian; Promeneur, Dominique; Rojek, Aleksandra; Kumar, Nirbhay; Frøkiaer, Jørgen; Nielsen, Søren; King, Landon S; Agre, Peter; Carbrey, Jennifer M.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 30, 24.07.2007, p. 12560-4.

A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.

Nedvetsky, Pavel I; Stefan, Eduard; Frische, Sebastian; Santamaria, Katja; Wiesner, Burkhard; Valenti, Giovanna; Hammer, John A; Nielsen, Søren; Goldenring, James R; Rosenthal, Walter; Klussmann, Enno.
Traffic (Copenhagen, Denmark), Vol. 8, No. 2, 02.2007, p. 110-23.

Candesartan prevents long-term impairment of renal function in response to neonatal partial unilateral ureteral obstruction.

Topcu, Sukru Oguzkan; Pedersen, Michael; Nørregaard, Rikke; Wang, Guixian; Knepper, Mark; Djurhuus, Jens Christian; Nielsen, Søren; Jørgensen, Troels Munch; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 292, No. 2, 02.2007, p. F736-48.

Cellular and subcellular distribution of the type-2 vasopressin receptor in the kidney.

Fenton, Robert A; Brønd, Lone; Nielsen, Søren; Praetorius, Jeppe.
A J P: Renal Physiology (Online), Vol. 293, No. 3, 09.2007, p. F748-60.

Correlation Between AVPR2 Mutations and Urinary AQP2 Excretion in Patients with Nephrogenic Diabetes Insipidus.

Kotnik, P.; Battelino, T.; Debeljak, M.; Podkrajsek, K.T.; Waldhauser, F.; Frøkiaer, J.; Nielsen, Søren; Krzisnik, C.
Journal of Pediatric Endocrinology & Metabolism, Vol. 20, No. 4, 2007, p. 483-489.

COX-2 activity transiently contributes to increased water and NaCl excretion in the polyuric phase after release of ureteral obstruction.

Nørregaard, Rikke; Jensen, Boye L; Topcu, Sukru Oguzkan; Diget, Maria; Schweer, Horst; Knepper, Mark A; Nielsen, Søren; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 292, No. 5, 2007, p. F1322-33.

Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice.

Rojek, Aleksandra M; Skowronski, Mariusz T; Füchtbauer, Ernst-Martin; Füchtbauer, Annette C; Fenton, Robert A; Agre, Peter; Frøkiaer, Jørgen; Nielsen, Søren.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 9, 27.02.2007, p. 3609-14.

Differential down-regulation of aquaporin-2 in rat kidney zones by peripheral nociceptin/orphanin FQ receptor agonism and vasopressin type-2 receptor antagonism.

Hadrup, Niels; Petersen, Jørgen S; Windfeld, Søren; Risom, Lotte; Andersen, Claus B; Nielsen, Søren; Christensen, Sten; Jonassen, Thomas E N.
The Journal of Pharmacology and Experimental Therapeutics, Vol. 323, No. 2, 11.2007, p. 516-24.

Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct.

Hoffert, Jason D; Nielsen, Jakob; Yu, Ming-Jiun; Pisitkun, Trairak; Schleicher, Stephen M; Nielsen, Soren; Knepper, Mark A.
A J P: Renal Physiology (Online), Vol. 292, No. 2, 02.2007, p. F691-700.

Expression of aquaporin-1 in endometrial blood vessels in menorrhagia.

Mints, M.; Hildenbrand, A.; Lalitkumar, L.P.; Andersson, S.; Nielsen, Søren; Gemzell-Danielsson, K.; Stavreus-Evers, A.
International Journal of Molecular Medicine, Vol. 19, No. 3, 2007, p. 407-411.

Furosemide increases water content in renal tissue.

Pedersen, Michael; Vajda, Zsolt; Stødkilde-Jørgensen, Hans; Nielsen, Søren; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 292, No. 5, 2007, p. F1645-51.

Gender differences in nighttime plasma arginine vasopressin and delayed compensatory urine output in the elderly population after desmopressin.

Hvistendahl, Gitte M; Frøkiaer, Jørgen; Nielsen, Søren; Djurhuus, Jens Christian.
Journal of Urology, Vol. 178, No. 6, 12.2007, p. 2671-6.

Increased AQP2 targeting in primary cultured IMCD cells in response to angiotensin II through AT1 receptor.

Lee, Yu-Jung; Song, In-Kyung; Jang, Kyung-Jin; Nielsen, Jakob; Frøkiaer, Jørgen; Nielsen, Søren; Kwon, Tae-Hwan.
A J P: Renal Physiology (Online), Vol. 292, No. 1, 01.2007, p. F340-50.

Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in inhibition of channel function.

Huang, Chunfa; Sindic, Aleksandra; Hill, Ceredwyn E; Hujer, Kristine M; Chan, Kim W; Sassen, Martin; Wu, Zhenzhen; Kurachi, Yoshihisa; Nielsen, Soren; Romero, Michael F; Miller, R Tyler.
A J P: Renal Physiology (Online), Vol. 292, No. 3, 03.2007, p. F1073-81.

Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney.

de Seigneux, Sophie; Nielsen, Jakob; Olesen, Emma T B; Dimke, Henrik; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 293, No. 1, 07.2007, p. F87-99.

Losartan decreases vasopressin-mediated cAMP accumulation in the thick ascending limb of the loop of Henle in rats with congestive heart failure.

Torp, M; Brønd, L; Hadrup, N; Nielsen, J B; Praetorius, J; Nielsen, Søren; Christensen, S; Jonassen, T E N.
Acta Physiologica (Print), Vol. 190, No. 4, 08.2007, p. 339-50.

Maintained ENaC trafficking in aldosterone-infused rats during mineralocorticoid and glucocorticoid receptor blockade.

Nielsen, Jakob; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Knepper, Mark A; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 292, No. 1, 01.2007, p. F382-94.

Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues.

Damkier, Helle Hasager; Nielsen, Søren; Praetorius, Jeppe.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 293, No. 5, 11.2007, p. R2136-46.

Origin and fate of pendrin-positive intercalated cells in developing mouse kidney.

Song, Hyun-Kuk; Kim, Wan-Young; Lee, Hyun-Wook; Park, Eun-Young; Han, Ki-Hwan; Nielsen, Soren; Madsen, Kirsten M; Kim, Jin.
Journal of the American Society of Nephrology, Vol. 18, No. 10, 2007, p. 2672-82.

PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice.

Ahrabi, Ali K; Terryn, Sara; Valenti, Giovanna; Caron, Nathalie; Serradeil-Le Gal, Claudine; Raufaste, Danielle; Nielsen, Soren; Horie, Shigeo; Verbavatz, Jean-Marc; Devuyst, Olivier.
Journal of the American Society of Nephrology, Vol. 18, No. 6, 06.2007, p. 1740-53.

Regulation and dysregulation of aquaporins in water balance disorders.

Nielsen, Søren; Kwon, T-H; Frøkiaer, J; Agre, P.
Journal of Internal Medicine, Vol. 261, No. 1, 01.2007, p. 53-64.

Renal compensation to chronic hypoxic hypercapnia: downregulation of pendrin and adaptation of the proximal tubule.

de Seigneux, Sophie; Malte, Hans; Dimke, Henrik; Frøkiaer, Jørgen; Nielsen, Søren; Frische, Sebastian.
A J P: Renal Physiology (Online), Vol. 292, No. 4, 04.2007, p. F1256-66.

Therapeutically active α-MSH analogues.

Jonassen, Thomas Engelbrecht Nordkild (Inventor); Nielsen, Søren (Inventor); Frøkiær, Jørgen (Inventor); Larsen, Bjarne Due (Inventor).
Patent No.: WO/2007/022774. Mar 01, 2007.

Vacuolar H+-ATPase expression is increased in acid-secreting intercalated cells in kidneys of rats with hypercalcaemia-induced alkalosis.

Wang, W; Praetorius, J; Li, C; Praetorius, H A; Kwon, T-H; Frøkiaer, J; Nielsen, Søren.
Acta Physiologica (Print), Vol. 189, No. 4, 04.2007, p. 359-68.
2006

Aldosterone increases urine production and decreases apical AQP2 expression in rats with diabetes insipidus.

Nielsen, Jakob; Kwon, Tae-Hwan; Praetorius, Jeppe; Frøkiaer, Jørgen; Knepper, Mark A; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 290, No. 2, 02.2006, p. F438-49.

alpha-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction.

Li, Chunling; Shi, Yimin; Wang, Weidong; Sardeli, Chrysanthi; Kwon, Tae-Hwan; Thomsen, Klaus; Jonassen, Thomas; Djurhuus, Jens Christian; Knepper, Mark A; Nielsen, Søren; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 290, No. 2, 02.2006, p. F384-96.

An anti-NH2-terminal antibody localizes NBCn1 to heart endothelia and skeletal and vascular smooth muscle cells.

Damkier, Helle Hasager; Nielsen, Søren; Praetorius, Jeppe.
American Journal of Physiology: Heart and Circulatory Physiology, Vol. 290, No. 1, 01.2006, p. H172-80.

Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction.

Jensen, Anja M; Li, Chunling; Praetorius, Helle A; Nørregaard, Rikke; Frische, Sebastian; Knepper, Mark A; Nielsen, Søren; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 291, No. 5, 11.2006, p. F1021-32.

Aquaporin-11: a channel protein lacking apparent transport function expressed in brain.

Gorelick, Daniel A; Praetorius, Jeppe; Tsunenari, Takashi; Nielsen, Søren; Agre, Peter.
B M C Biochemistry, Vol. 7, 2006, p. 14.

Biphasic changes of epithelial sodium channel abundance and trafficking in common bile duct ligation-induced liver cirrhosis.

Kim, S W; Wang, W; Sassen, M C; Choi, K C; Han, J S; Knepper, M A; Jonassen, T E N; Frøkiaer, J; Nielsen, Søren.
Kidney International, Vol. 69, No. 1, 01.2006, p. 89-98.

Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking.

Wang, Weidong; Li, Chunling; Nejsum, Lene N; Li, Hongyan; Kim, Soo Wan; Kwon, Tae-Hwan; Jonassen, Thomas E N; Knepper, Mark A; Thomsen, Klaus; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 290, No. 2, 02.2006, p. F530-41.

Distribution of sodium transporters and aquaporin-1 in the human choroid plexus.

Praetorius, Jeppe; Nielsen, Søren.
American Journal of Physiology: Cell Physiology, Vol. 291, No. 1, 07.2006, p. C59-67.

Dysregulation of renal sodium transporters in gentamicin-treated rats.

Sassen, M C; Kim, S W; Kwon, T-H; Knepper, M A; Miller, R T; Frøkiaer, J; Nielsen, Søren.
Kidney International, Vol. 70, No. 6, 09.2006, p. 1026-37.

Expression of protein kinase C isoenzymes alpha, betaI, and delta in subtypes of intercalated cells of mouse kidney.

Kim, Wan-Young; Jung, Joon-Ho; Park, Eun-Young; Yang, Chul-Woo; Kim, Hyang; Nielsen, Søren; Madsen, Kirsten M; Kim, Jin.
A J P: Renal Physiology (Online), Vol. 291, No. 5, 11.2006, p. F1052-60.

Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats.

Kim, Soo Wan; de Seigneux, Sophie; Sassen, Martin C; Lee, JongUn; Kim, Jin; Knepper, Mark A; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 290, No. 3, 03.2006, p. F674-87.

Lithium-induced NDI in rats is associated with loss of alpha-ENaC regulation by aldosterone in CCD.

Nielsen, Jakob; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Knepper, Mark A; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 290, No. 5, 05.2006, p. F1222-33.

Lithium treatment induces a marked proliferation of primarily principal cells in rat kidney inner medullary collecting duct.

Christensen, Birgitte Mønster; Kim, Young-Hee; Kwon, Tae-Hwan; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 291, No. 1, 07.2006, p. F39-48.

Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response?

Kelsen, Jesper; Kjaer, Katrine; Chen, Gang; Pedersen, Michael; Røhl, Lisbeth; Frøkiaer, Jørgen; Nielsen, Søren; Nyengaard, Jens R; Rønn, Lars Christian B.
Journal of Neuroinflammation, Vol. 3, No. 1, 2006, p. 31.

Posttranscriptional control of aquaporin-2 abundance by vasopressin in renal collecting duct principal cells.

Hasler, Udo; Nielsen, Søren; Féraille, Eric; Martin, Pierre-Yves.
A J P: Renal Physiology (Online), Vol. 290, No. 1, 01.2006, p. F177-87.

Severe urinary concentrating defect in renal collecting duct-selective AQP2 conditional-knockout mice.

Rojek, Aleksandra; Füchtbauer, Ernst-Martin; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Nielsen, Søren.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 15, 11.04.2006, p. 6037-42.

Successful treatment of a patient with primary Sjögren’s syndrome with Rituximab.

Ring, Troels; Kallenbach, Maria; Praetorius, Jeppe; Nielsen, Søren; Melgaard, Birgitte.
Clinical Rheumatology, Vol. 25, No. 6, 11.2006, p. 891-4.

The role of aquaporin water channels in fluid secretion by the exocrine pancreas.

Burghardt, B; Nielsen, Søren; Steward, M C.
Journal of Membrane Biology, Vol. 210, No. 2, 03.2006, p. 143-53.

Urinary aquaporin-2 in children with acute pyelonephritis.

Rodionova, Elena A; Kuznetsova, Alla A; Shakhmatova, Elena I; Prutskova, Natalia; Nielsen, Søren; Holtbäck, Ulla; Natochin, Yuri; Zelenina, Marina.
Pediatric nephrology (Berlin, Germany), Vol. 21, No. 3, 03.2006, p. 361-7.

Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus.

Kotnik, Primoz; Nielsen, Jakob; Kwon, Tae-Hwan; Krzisnik, Ciril; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 288, No. 5, 05.2005, p. F1053-68.

Altered expression of selected genes in kidney of rats with lithium-induced NDI.

Rojek, Aleksandra; Nielsen, Jakob; Brooks, Heddwen L; Gong, Hong; Kim, Young-Hee; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 288, No. 6, 06.2005, p. F1276-89.

Bidirectional regulation of AQP2 trafficking and recycling: involvement of AQP2-S256 phosphorylation.

Nejsum, Lene N; Zelenina, Marina; Aperia, Anita; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 288, No. 5, 05.2005, p. F930-8.

COX-2 inhibition prevents downregulation of key renal water and sodium transport proteins in response to bilateral ureteral obstruction.

Nørregaard, Rikke; Jensen, Boye L; Li, Chunling; Wang, Weidong; Knepper, Mark A; Nielsen, Søren; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 289, No. 2, 08.2005, p. F322-33.

Decreased expression of AQP2 and AQP4 water channels and Na,K-ATPase in kidney collecting duct in AQP3 null mice.

Kim, Soo Wan; Gresz, Veronika; Rojek, Aleksandra; Wang, Weidong; Verkman, A S; Frøkiaer, Jørgen; Nielsen, Søren.
Molecular and Cellular Biology, Vol. 97, No. 10, 10.2005, p. 765-78.

Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland.

Ishikawa, Yasuko; Yuan, Zhenfang; Inoue, Noriko; Skowronski, Mariusz T; Nakae, Yoshiko; Shono, Masayuki; Cho, Gota; Yasui, Masato; Agre, Peter; Nielsen, Søren.
American Journal of Physiology: Cell Physiology, Vol. 289, No. 5, 11.2005, p. C1303-11.

Increased apical targeting of renal epithelial sodium channel subunits and decreased expression of type 2 11beta-hydroxysteroid dehydrogenase in rats with CCl4-induced decompensated liver cirrhosis.

Kim, Soo Wan; Schou, Uffe K; Peters, Christian D; de Seigneux, Sophie; Kwon, Tae-Hwan; Knepper, Mark A; Jonassen, Thomas E N; Frøkiaer, Jørgen; Nielsen, Søren.
Journal of the American Society of Nephrology, Vol. 16, No. 11, 11.2005, p. 3196-210.

Increased expression of ENaC subunits and increased apical targeting of AQP2 in the kidneys of spontaneously hypertensive rats.

Kim, Soo Wan; Wang, Weidong; Kwon, Tae-Hwan; Knepper, Mark A; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 289, No. 5, 11.2005, p. F957-68.

Intercalated cell H+/OH- transporter expression is reduced in Slc26a4 null mice.

Kim, Young-Hee; Verlander, Jill W; Matthews, Sharon W; Kurtz, Ira; Shin, Wonkyong; Weiner, I David; Everett, Lorraine A; Green, Eric D; Nielsen, Søren; Wall, Susan M.
A J P: Renal Physiology (Online), Vol. 289, No. 6, 12.2005, p. F1262-72.

Magnesium depletion enhances cisplatin-induced nephrotoxicity.

Lajer, H; Kristensen, M; Hansen, H H; Nielsen, Søren; Frøkiaer, J; Ostergaard, L F; Christensen, S; Daugaard, G; Jonassen, T E N.
Cancer Chemotherapy and Pharmacology, Vol. 56, No. 5, 11.2005, p. 535-42.

Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury.

Møller-Kristensen, M; Wang, W; Ruseva, M; Thiel, S; Nielsen, Søren; Takahashi, K; Shi, L; Ezekowitz, A; Jensenius, J C; Gadjeva, M.
Scandinavian Journal of Immunology. Supplement, Vol. 61, No. 5, 05.2005, p. 426-34.

Na+-dependent HCO3- uptake into the rat choroid plexus epithelium is partially DIDS sensitive.

Bouzinova, Elena V; Praetorius, Jeppe; Virkki, Leila V; Nielsen, Søren; Boron, Walter F; Aalkjaer, Christian.
American Journal of Physiology: Cell Physiology, Vol. 289, No. 6, 12.2005, p. C1448-56.

NKCC1 and NHE1 are abundantly expressed in the basolateral plasma membrane of secretory coil cells in rat, mouse, and human sweat glands.

Nejsum, Lene N; Praetorius, Jeppe; Nielsen, Søren.
American Journal of Physiology: Cell Physiology, Vol. 289, No. 2, 08.2005, p. C333-40.
2004

AE2 isoforms in rat kidney: immunohistochemical localization and regulation in response to chronic NH4Cl loading.

Frische, Sebastian; Zolotarev, Alexander S; Kim, Young-Hee; Praetorius, Jeppe; Alper, Seth; Nielsen, Søren; Wall, Susan M.
A J P: Renal Physiology (Online), Vol. 286, No. 6, 06.2004, p. F1163-70.

Altered expression of urea transporters in response to ureteral obstruction.

Li, Chunling; Klein, Janet D; Wang, Weidong; Knepper, Mark A; Nielsen, Søren; Sands, Jeff M; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 286, No. 6, 06.2004, p. F1154-62.

Aquaporins and the central nervous system.

Sulyok, E; Vajda, Z; Dóczi, T; Nielsen, Søren.
Acta Neurochirurgica, Vol. 146, No. 9, 09.2004, p. 955-60.

A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells.

Praetorius, J; Nejsum, L N; Nielsen, Søren.
American Journal of Physiology: Cell Physiology, Vol. 286, No. 3, 03.2004, p. C601-C610.

Basolateral Na+-dependent HCO3- transporter NBCn1-mediated HCO3- influx in rat medullary thick ascending limb.

Odgaard, Elvin; Jakobsen, Jakob K; Frische, Sebastian; Praetorius, Jeppe; Nielsen, Søren; Aalkjaer, Christian; Leipziger, Jens.
Journal of Physiology, Vol. 555, No. Pt 1, 15.02.2004, p. 205-18.

Beta1-integrins in the primary cilium of MDCK cells potentiate fibronectin-induced Ca2+ signaling.

Praetorius, H A; Praetorius, J; Nielsen, Søren; Frokiaer, J; Spring, K R.
A J P: Renal Physiology (Online), Vol. 287, No. 5, 11.2004, p. F969-78.

Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI.

Christensen, Birgitte Mønster; Marples, David; Kim, Young-Hee; Wang, Weidong; Frøkiaer, Jørgen; Nielsen, Søren.
American Journal of Physiology: Cell Physiology, Vol. 286, No. 4, 04.2004, p. C952-C964.

Changes of rat kidney AQP2 and Na,K-ATPase mRNA expression in lithium-induced nephrogenic diabetes insipidus.

Laursen, Ulla Helt; Pihakaski-Maunsbach, Kaarina; Kwon, Tae-Hwan; Østergaard Jensen, Erik; Nielsen, Søren; Maunsbach, Arvid B.
Nephron Clinical Practice, Vol. 97, No. 1, 2004, p. e1-16.

Chronic nitric oxide synthase inhibition exacerbates renal dysfunction in cirrhotic rats.

Graebe, Martin; Brond, Lone; Christensen, Sten; Nielsen, Soren; Olsen, Niels V; Jonassen, Thomas E N.
A J P: Renal Physiology (Online), Vol. 286, No. 2, 02.2004, p. F288-F297.

Early release of neonatal ureteral obstruction preserves renal function.

Shi, Yimin; Pedersen, Michael; Li, Chunling; Wen, Jian Guo; Thomsen, Klaus; Stødkilde-Jørgensen, Hans; Jørgensen, Troels Munch; Knepper, Mark A; Nielsen, Søren; Djurhuus, Jens Christian; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 286, No. 6, 06.2004, p. F1087-99.

Effects of microgravity on organ development of the neonatal rat.

Miyake, Masao; Yamasaki, Masao; Hazama, Akihiro; Nielsen, Soren; Shimizu, Tsuyoshi.
biological science space, Vol. 18, No. 3, 11.2004, p. 126-7.

EPO and alpha-MSH prevent ischemia/reperfusion-induced down-regulation of AQPs and sodium transporters in rat kidney.

Gong, Hong; Wang, Weidong; Kwon, Tae-Hwan; Jonassen, Thomas; Li, Chunling; Ring, Troels; Frokiaer, J; Nielsen, Søren.
Kidney International, Vol. 66, No. 2, 08.2004, p. 683-95.

Expression of aquaporin isoforms during human and mouse tooth development.

Felszeghy, S; Módis, L; Németh, P; Nagy, G; Zelles, T; Agre, P; Laurikkala, J; Fejerskov, O; Thesleff, I; Nielsen, Søren.
Archives of Oral Biology, Vol. 49, No. 4, 04.2004, p. 247-57.

Functional up-regulation of basolateral Na+-dependent HCO3- transporter NBCn1 in medullary thick ascending limb of K+-depleted rats.

Jakobsen, Jakob K; Odgaard, Elvin; Wang, Weidong; Elkjaer, Marie Louise; Nielsen, Søren; Aalkjaer, Christian; Leipziger, Jens.
Pflügers Archiv – European Journal of Physiology, Vol. 448, No. 6, 09.2004, p. 571-8.

Immunolocalization of AQP-5 in rat parotid and submandibular salivary glands after stimulation or inhibition of secretion in vivo.

Gresz, Veronika; Kwon, Tae-Hwan; Gong, Hong; Agre, Peter; Steward, Martin C; King, Landon S; Nielsen, Søren.
American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 287, No. 1, 07.2004, p. G151-61.

Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats.

Kim, Soo Wan; Wang, Weidong; Nielsen, Jakob; Praetorius, Jeppe; Kwon, Tae-Hwan; Knepper, Mark A; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 286, No. 5, 05.2004, p. F922-35.

Intravenous fluids for seriously ill children.

Vajda, Zs; Sulyok, E; Dóczi, T; Nielsen, Søren.
The Lancet (North American Edition), Vol. 363, No. 9404, 17.01.2004, p. 241; author reply 242.

NBCn1 is a basolateral Na+-HCO3- cotransporter in rat kidney inner medullary collecting ducts.

Praetorius, Jeppe; Kim, Young-Hee; Bouzinova, Elena V; Frische, Sebastian; Rojek, Aleksandra; Aalkjaer, Christian; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 286, No. 5, 05.2004, p. F903-12.

Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation.

Hadrup, Niels; Petersen, Jørgen S; Praetorius, Jeppe; Meier, Eddi; Graebe, Martin; Brønd, Lone; Staahltoft, Dennis; Nielsen, Søren; Christensen, Sten; Kapusta, Daniel R; Jonassen, Thomas E N.
A J P: Renal Physiology (Online), Vol. 287, No. 1, 07.2004, p. F160-8.

Peter Agre, 2003 Nobel Prize winner in chemistry.

Knepper, Mark A; Nielsen, Soren.
Journal of the American Society of Nephrology, Vol. 15, No. 4, 04.2004, p. 1093-5.

Reduced expression of renal Na+ transporters in rats with PTH-induced hypercalcemia.

Wang, Weidong; Li, Chunling; Kwon, Tae-Hwan; Miller, R Tyler; Knepper, Mark A; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 286, No. 3, 03.2004, p. F534-45.

Sodium coupled bicarbonate transporters in the kidney, an update.

Aalkjaer, C; Frische, S; Leipziger, J; Nielsen, Søren; Praetorius, J.
Acta Physiologica Scandinavica, Vol. 181, No. 4, 08.2004, p. 505-12.

The basolateral expression of mUT-A3 in the mouse kidney.

Stewart, Gavin S; Fenton, Robert A; Wang, Weidong; Kwon, Tae-Hwan; White, Stanley J; Collins, Valerie M; Cooper, Gordon; Nielsen, Søren; Smith, Craig P.
A J P: Renal Physiology (Online), Vol. 286, No. 5, 05.2004, p. F979-87.

Uncoupling of vasopressin signaling in collecting ducts from rats with CBL-induced liver cirrhosis.

Brønd, Lone; Hadrup, Niels; Salling, Nanna; Torp, Malene; Graebe, Martin; Christensen, Sten; Nielsen, Søren; Jonassen, Thomas E N.
A J P: Renal Physiology (Online), Vol. 287, No. 4, 10.2004, p. F806-15.

Altered expression of major renal Na transporters in rats with bilateral ureteral obstruction and release of obstruction.

Li, Chunling; Wang, Weidong; Kwon, Tae-Hwan; Knepper, Mark A; Nielsen, Søren; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 285, No. 5, 11.2003, p. F889-901.

Altered expression of major renal Na transporters in rats with unilateral ureteral obstruction.

Li, Chunling; Wang, Weidong; Kwon, Tae-Hwan; Knepper, Mark A; Nielsen, Soren; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 284, No. 1, 01.2003, p. F155-66.

Altered expression of renal acid-base transporters in rats with lithium-induced NDI.

Kim, Young-Hee; Kwon, Tae-Hwan; Christensen, Birgitte M; Nielsen, Jakob; Wall, Susan M; Madsen, Kirsten M; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 285, No. 6, 12.2003, p. F1244-57.

AQP1 and AQP3, psoriasin, and nitric oxide synthases 1-3 are inflammatory mediators in erythema toxicum neonatorum.

Marchini, Giovanna; Ståbi, Berit; Kankes, Kanchana; Lonne-Rahm, Solbritt; Østergaard, Morten; Nielsen, Søren.
Pediatric Dermatology, Vol. 20, No. 5, 03.10.2003, p. 377-84.

Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver.

Carbrey, Jennifer M; Gorelick-Feldman, Daniel A; Kozono, David; Praetorius, Jeppe; Nielsen, Soren; Agre, Peter.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, No. 5, 04.03.2003, p. 2945-50.

Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin.

Christensen, Birgitte Mønster; Wang, Weidong; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 284, No. 4, 04.2003, p. F701-17.

Bending the primary cilium opens Ca2+-sensitive intermediate-conductance K+ channels in MDCK cells.

Praetorius, H A; Frokiaer, J; Nielsen, Søren; Spring, K R.
Journal of Membrane Biology, Vol. 191, No. 3, 01.02.2003, p. 193-200.

cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion.

Brooks, Heddwen L; Ageloff, Shana; Kwon, Tae-Hwan; Brandt, William; Terris, James M; Seth, Akhil; Michea, Luis; Nielsen, Soren; Fenton, Robert; Knepper, Mark A.
A J P: Renal Physiology (Online), Vol. 284, No. 1, 01.2003, p. F218-28.

Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas.

Burghardt, B; Elkaer, M-L; Kwon, T-H; Rácz, G Z; Varga, G; Steward, M C; Nielsen, Søren.
Gut, Vol. 52, No. 7, 07.2003, p. 1008-16.

Downregulation of renal aquaporins in response to unilateral ureteral obstruction.

Li, Chunling; Wang, Weidong; Knepper, Mark A; Nielsen, Søren; Frøkiaer, Jørgen.
A J P: Renal Physiology (Online), Vol. 284, No. 5, 05.2003, p. F1066-79.

Effects of renal denervation on tubular sodium handling in rats with CBL-induced liver cirrhosis.

Jonassen, Thomas E N; Brønd, Lone; Torp, Malene; Graebe, Martin; Nielsen, Søren; Skøtt, Ole; Marcussen, Niels; Christensen, Sten.
A J P: Renal Physiology (Online), Vol. 284, No. 3, 03.2003, p. F555-63.

Electrogenic Na+/HCO3- cotransporter rkNBC1 immunolocalized in rat eye.

Vorum, Henrik; Aalkjaer, Christian; Hager, Henrik; Nielsen, Søren; Maunsbach, Arvid B.
Annals of the New York Academy of Sciences, Vol. 986, 04.2003, p. 646-648.

Increased urinary excretion of aquaporin 2 in patients with liver cirrhosis.

Ivarsen, P; Frøkiaer, J; Aagaard, N K; Hansen, E F; Bendtsen, F; Nielsen, Søren; Vilstrup, H.
Gut, Vol. 52, No. 8, 08.2003, p. 1194-1199.

Molecular pathogenesis of nephrogenic diabetes insipidus.

Nguyen, Minhtri K; Nielsen, Søren; Kurtz, Ira.
Clinical Nephrology, Vol. 7, No. 1, 03.2003, p. 9-17.

Nobelprisen i kemi år 2003 til Peter Agre for opdagelsen af aquaporinvandkanaler.

Nielsen, Søren.
Ugeskrift for læger, No. 165, 12.2003, p. 4863-4865.

P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport.

Köttgen, Michael; Löffler, Thomas; Jacobi, Christoph; Nitschke, Roland; Pavenstädt, Hermann; Schreiber, Rainer; Frische, Sebastian; Nielsen, Søren; Leipziger, Jens.
Journal of Clinical Investigation, Vol. 111, No. 3, 02.2003, p. 371-9.

Reduced renal expression of AQP2, p-AQP2 and AQP3 in haemorrhagic shock-induced acute renal failure.

Gong, Hong; Wang, Weidong; Kwon, Tae-Hwan; Jonassen, Thomas; Frøkiaer, Jørgen; Nielsen, Søren.
Nephrology, Dialysis, Transplantation, Vol. 18, No. 12, 12.2003, p. 2551-2559.

Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading.

Frische, Sebastian; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Madsen, Kirsten M; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 284, No. 3, 03.2003, p. F584-93.

Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II.

Kwon, Tae-Hwan; Nielsen, Jakob; Kim, Young-Hee; Knepper, Mark A; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 285, No. 1, 07.2003, p. F152-65.

Renal aquaporins and sodium transporters with special focus on urinary tract obstruction.

Frøkiaer, Jørgen; Li, Chunling; Shi, Yimin; Jensen, Anja; Praetorius, Helle; Hansen, Helle; Topcu, Oguz; Sardeli, Chrysanthi; Wang, Weidong; Kwon, Tae-Hwan; Nielsen, Søren.
APMIS – Journal of Pathology, Microbiology and Immunology, No. 109, 2003, p. 71-9.

Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI.

Nielsen, Jakob; Kwon, Tae-Hwan; Praetorius, Jeppe; Kim, Young-Hee; Frøkiaer, Jørgen; Knepper, Mark A; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 285, No. 6, 12.2003, p. F1198-209.

Ser-256 phosphorylation dynamics of Aquaporin 2 during maturation from the ER to the vesicular compartment in renal cells.

Procino, Giuseppe; Carmosino, Monica; Marin, Oriano; Brunati, Anna M; Contri, Antonella; Pinna, Lorenzo A; Mannucci, Roberta; Nielsen, Soren; Kwon, Tae-Hwan; Svelto, Maria; Valenti, Giovanna.
F A S E B Journal, Vol. 17, No. 13, 10.2003, p. 1886-8.

Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure.

Sheikh-Hamad, David; Bick, Roger; Wu, Gang-Yi; Christensen, Birgitte Mønster; Razeghi, Peter; Poindexter, Brian; Taegtmeyer, Heinrich; Wamsley, Ann; Padda, Ranjit; Entman, Mark; Nielsen, Søren; Youker, Keith.
American Journal of Physiology: Heart and Circulatory Physiology, Vol. 285, No. 1, 07.2003, p. H442-8.

Transepidermal water loss in developing rats: role of aquaporins in the immature skin.

Agren, Johan; Zelenin, Sergey; Håkansson, Mattias; Eklöf, Ann-Christine; Aperia, Anita; Nejsum, Lene N; Nielsen, Soren; Sedin, Gunnar.
Pediatric Research, Vol. 53, No. 4, 04.2003, p. 558-65.
2002

AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct.

Ko, Shigeru B H; Luo, Xiang; Hager, Henrik; Rojek, Alexandra; Choi, Joo Young; Licht, Christoph; Suzuki, Makoto; Muallem, Shmuel; Nielsen, Søren; Ishibashi, Kenichi.
American Journal of Physiology: Cell Physiology, Vol. 283, No. 4, 10.2002, p. C1206-18.

Altered expression of renal NHE3, TSC, BSC-1, and ENaC subunits in potassium-depleted rats.

Elkjaer, Marie-Louise; Kwon, Tae-Hwan; Wang, Weidong; Nielsen, Jakob; Knepper, Mark A; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 283, No. 6, 12.2002, p. F1376-88.

AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors.

Wang, Weidong; Li, Chunling; Kwon, Tae-Hwan; Knepper, Mark A; Frøkiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 283, No. 6, 12.2002, p. F1313-25.

Aquaporins in the kidney: from molecules to medicine.

Nielsen, Søren; Frøkiaer, Jørgen; Marples, David; Kwon, Tae-Hwan; Agre, Peter; Knepper, Mark A.
Physiological Research, Vol. 82, No. 1, 01.2002, p. 205-44.

Aquaporin water channels–from atomic structure to clinical medicine.

Agre, Peter; King, Landon S; Yasui, Masato; Guggino, Wm B; Ottersen, Ole Petter; Fujiyoshi, Yoshinori; Engel, Andreas; Nielsen, Søren.
Journal of Physiology, Vol. 542, No. Pt 1, 01.07.2002, p. 3-16.

Chronic metabolic acidosis upregulates rat kidney Na-HCO cotransporters NBCn1 and NBC3 but not NBC1.

Kwon, Tae-Hwan; Fulton, Christiaan; Wang, Weidong; Kurtz, Ira; Frøkiaer, Jørgen; Aalkjaer, Christian; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 282, No. 2, 02.2002, p. F341-51.

Decreased abundance of collecting duct urea transporters UT-A1 and UT-A3 with ECF volume expansion.

Wang, Xiao-Yan; Beutler, Kathleen; Nielsen, Jakob; Nielsen, Søren; Knepper, Mark A; Masilamani, Shyama.
A J P: Renal Physiology (Online), Vol. 282, No. 4, 04.2002, p. F577-84.

Decreased pulmonary vascular permeability in aquaporin-1-null humans.

King, Landon S; Nielsen, Søren; Agre, Peter; Brown, Robert H.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 2, 22.01.2002, p. 1059-63.

Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice.

Vajda, Zsolt; Pedersen, Michael; Füchtbauer, Ernst-Martin; Wertz, Karin; Stødkilde-Jørgensen, Hans; Sulyok, Endre; Dóczi, Tamás; Neely, John D; Agre, Peter; Frøkiaer, Jørgen; Nielsen, Søren.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 20, 01.10.2002, p. 13131-6.

Endonuclein is a cell cycle regulated WD-repeat protein that is up-regulated in adenocarcinoma of the pancreas.

Honoré, Bent; Baandrup, Ulrik; Nielsen, Søren; Vorum, Henrik.
Oncogene, Vol. 21, No. 7, 07.02.2002, p. 1123-9.

Functional requirement of aquaporin-5 in plasma membranes of sweat glands.

Nejsum, Lene N; Kwon, Tae-Hwan; Jensen, Uffe B; Fumagalli, Ornella; Frøkiaer, Jørgen; Krane, Carissa M; Menon, Anil G; King, Landon S; Agre, Peter C; Nielsen, Søren.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 1, 08.01.2002, p. 511-6.

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.

Schlingmann, Karl P; Weber, Stefanie; Peters, Melanie; Niemann Nejsum, Lene; Vitzthum, Helga; Klingel, Karin; Kratz, Markus; Haddad, Elie; Ristoff, Ellinor; Dinour, Dganit; Syrrou, Maria; Nielsen, Søren; Sassen, Martin; Waldegger, Siegfried; Seyberth, Hannsjörg W; Konrad, Martin.
Nature Genetics, Vol. 31, No. 2, 06.2002, p. 166-70.

Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney.

Kim, Young-Hee; Kwon, Tae-Hwan; Frische, Sebastian; Kim, Jin; Tisher, C Craig; Madsen, Kirsten M; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 283, No. 4, 10.2002, p. F744-54.

Immunolocalization of electroneutral Na(+)-HCO cotransporters in human and rat salivary glands.

Gresz, V; Kwon, T-H; Vorum, H; Zelles, T; Kurtz, I; Steward, M C; Aalkjaer, C; Nielsen, Søren.
American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 283, No. 2, 08.2002, p. G473-80.

Lipopolysaccharide-induced acute renal failure in conscious rats: effects of specific phosphodiesterase type 3 and 4 inhibition.

Jonassen, Thomas E N; Graebe, Martin; Promeneur, Dominique; Nielsen, Søren; Christensen, Sten; Olsen, Niels V.
The Journal of Pharmacology and Experimental Therapeutics, Vol. 303, No. 1, 10.2002, p. 364-74.

Losartan treatment normalizes renal sodium and water handling in rats with mild congestive heart failure.

Staahltoft, Dennis; Nielsen, Søren; Janjua, Nadeem R; Christensen, Sten; Skøtt, Ole; Marcussen, Niels; Jonassen, Thomas E N.
A J P: Renal Physiology (Online), Vol. 282, No. 2, 02.2002, p. F307-15.

Reduced expression of Na-K-2Cl cotransporter in medullary TAL in vitamin D-induced hypercalcemia in rats.

Wang, Weidong; Kwon, Tae-Hwan; Li, Chunling; Frøkiaer, Jørgen; Knepper, Mark A; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 282, No. 1, 01.2002, p. F34-44.

Regulation of collecting duct AQP3 expression: response to mineralocorticoid.

Kwon, Tae-Hwan; Nielsen, Jakob; Masilamani, Shyama; Hager, Henrik; Knepper, Mark A; Frokiaer, Jørgen; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 283, No. 6, 12.2002, p. F1403-21.

Regulation of renal salt and water transporters during vasopressin escape.

Ecelbarger, Carolyn A; Murase, Takashi; Tian, Ying; Nielsen, Soren; Knepper, Mark A; Verbalis, Joseph G.
Progress in Brain Research, Vol. 139, 2002, p. 75-84.

The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel.

van Balkom, Bas W M; Savelkoul, Paul J M; Markovich, Daniel; Hofman, Erik; Nielsen, Soren; van der Sluijs, Peter; Deen, Peter M T.
Journal of Biological Chemistry, Vol. 277, No. 44, 01.11.2002, p. 41473-9.

Time course of renal Na-K-ATPase, NHE3, NKCC2, NCC, and ENaC abundance changes with dietary NaCl restriction.

Masilamani, Shyama; Wang, Xiaoyan; Kim, Gheun-Ho; Brooks, Heddwen; Nielsen, Jakob; Nielsen, Soren; Nakamura, Kenzo; Stokes, John B; Knepper, Mark A.
A J P: Renal Physiology (Online), Vol. 283, No. 4, 10.2002, p. F648-57.

Urinary aquaporin-2 excretion in preterm and full-term neonates.

Nyul, Z; Vajda, Zs; Vida, G; Sulyok, E; Frokiaer, J; Nielsen, Søren.
Biology of the Neonate, Vol. 82, No. 1, 2002, p. 17-21.
2001

Altered expression of renal aquaporins and Na(+) transporters in rats treated with L-type calcium blocker.

Wang, W; Kwon, T H; Li, C; Flyvbjerg, A; Knepper, M A; Frøkiaer, J; Nielsen, Søren.
American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 280, No. 6, 06.2001, p. R1632-41.

Aquaporins.

Hohmann, Stefan (Editor); Nielsen, Søren (Editor); Agre, Peter (Editor).
2001.
Research output: Anthology › Research › peer-review

Downregulation of AQP1, -2, and -3 after ureteral obstruction is associated with a long-term urine-concentrating defect.

Li, C; Wang, W; Kwon, T H; Isikay, L; Wen, J G; Marples, D; Djurhuus, J C; Stockwell, A; Knepper, M A; Nielsen, Søren; Frøkiaer, J.
A J P: Renal Physiology (Online), Vol. 281, No. 1, 07.2001, p. F163-71.

Effects of centrally administered arginine vasopressin and atrial natriuretic peptide on the development of brain edema in hyponatremic rats.

Vajda, Z; Pedersen, M; Dóczi, T; Sulyok, E; Stødkilde-Jørgensen, H; Frøkiaer, J; Nielsen, Søren.
Neurosurgery, Vol. 49, No. 3, 09.2001, p. 697-704; discussion 704-5.

Expression and immunolocalization of aquaporin water channels in rat exocrine pancreas.

Hurley, P T; Ferguson, C J; Kwon, T H; Andersen, M L; Norman, A G; Steward, M C; Nielsen, Søren; Case, R M.
American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 280, No. 4, 04.2001, p. G701-9.

Food restriction prevents age-related polyuria by vasopressin-dependent recruitment of aquaporin-2.

Combet, S; Teillet, L; Geelen, G; Pitrat, B; Gobin, R; Nielsen, Søren; Trinh-Trang-Tan, M M; Corman, B; Verbavatz, J M.
A J P: Renal Physiology (Online), Vol. 281, No. 6, 12.2001, p. F1123-31.

Identification and localization of aquaporin water channels in human salivary glands.

Gresz, V; Kwon, T H; Hurley, P T; Varga, G; Zelles, T; Nielsen, Søren; Case, R M; Steward, M C.
American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 281, No. 1, 07.2001, p. G247-54.

Identification of three new splice variants of the SNARE protein SNAP-23.

Shukla, A; Corydon, T J; Nielsen, Søren; Hoffmann, H J; Dahl, R.
Biochemical and Biophysical Research Communications, Vol. 285, No. 2, 13.07.2001, p. 320-7.

Immunocytochemical and immunoelectron microscopic localization of alpha-, beta-, and gamma-ENaC in rat kidney.

Hager, H; Kwon, T H; Vinnikova, A K; Masilamani, S; Brooks, H L; Frøkiaer, J; Knepper, M A; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 280, No. 6, 06.2001, p. F1093-106.

Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways.

Elkjaer, M L; Nejsum, L N; Gresz, V; Kwon, T H; Jensen, U B; Frøkiaer, J; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 281, No. 6, 12.2001, p. F1047-57.

Methods for treatment of diseases associated with inflammation under non-ischemic conditions.

Nielsen, Søren (Inventor); Frøkiær, Jørgen (Inventor); Jonassen, Thomas Engelbrecht Nordkild (Inventor); Bjerke, Thorbjørn (Inventor).
Patent No.: WO/2001/082953. Nov 08, 2001.

Molecular and functional evidence for electrogenic and electroneutral Na(+)-HCO(3)(-) cotransporters in murine duodenum.

Praetorius, J; Hager, H; Nielsen, Søren; Aalkjaer, C; Friis, U G; Ainsworth, M A; Johansen, T.
American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol. 280, No. 3, 03.2001, p. G332-43.

Physiology and pathophysiology of renal aquaporins.

Kwon, T H; Hager, H; Nejsum, L N; Andersen, M L; Frøkiaer, J; Nielsen, Søren.
Seminars in Nephrology, Vol. 21, No. 3, 05.2001, p. 231-8.

Primary gene structure and expression studies of rodent paracellin-1.

Weber, S; Schlingmann, K P; Peters, M; Nejsum, L N; Nielsen, Søren; Engel, H; Grzeschik, K H; Seyberth, H W; Gröne, H J; Nüsing, R; Konrad, M.
Journal of the American Society of Nephrology, Vol. 12, No. 12, 12.2001, p. 2664-72.

Regulated exocytosis in immune function: are SNARE-proteins involved?

Shukla, A; Berglund, L; Nielsen, L P; Nielsen, Søren; Hoffmann, H J; Dahl, R.
Respiratory Medicine, Vol. 95, No. 10, 10.2001, p. 773-80.

SNAP-25-associated Hrs-2 protein colocalizes with AQP2 in rat kidney collecting duct principal cells.

Shukla, A; Hager, H; Corydon, T J; Bean, A J; Dahl, R; Vajda, Z; Li, H; Hoffmann, H J; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 281, No. 3, 09.2001, p. F546-56.

SNARE proteins are critical for regulated exocytosis of ECP from human eosinophils.

Hoffmann, H J; Bjerke, T; Karawajczyk, M; Dahl, R; Knepper, M A; Nielsen, Søren.
Biochemical and Biophysical Research Communications, Vol. 282, No. 1, 23.03.2001, p. 194-9.

The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon.

Wang, X Y; Masilamani, S; Nielsen, J; Kwon, T H; Brooks, H L; Nielsen, Søren; Knepper, M A.
Journal of Clinical Investigation, Vol. 108, No. 2, 07.2001, p. 215-22.

Use of α-MSH and EPO for preventing or treating ischemic conditions.

Nielsen, Søren (Inventor); Frøkiær, Jørgen (Inventor); Jonassen, Thomas Engelbrecht Nordkild (Inventor); Bjerke, Thorbjørn (Inventor).
Patent No.: WO/2001/082952. Nov 08, 2001.

Altered expression of renal AQPs and Na(+) transporters in rats with lithium-induced NDI.

Kwon, T H; Laursen, U H; Marples, D; Maunsbach, A B; Knepper, M A; Frokiaer, J; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 279, No. 3, 09.2000, p. F552-64.

Effects of medium hypertonicity on water permeability in the mammalian rectum: ultrastructural and molecular correlates.

Kierbel, A; Capurro, C; Pisam, M; Gobin, R; Christensen, B M; Nielsen, Søren; Parisi, M.
Pflügers Archiv – European Journal of Physiology, Vol. 440, No. 4, 08.2000, p. 609-18.

Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene.

Yun, J; Schöneberg, T; Liu, J; Schulz, A; Ecelbarger, C A; Promeneur, D; Nielsen, Søren; Sheng, H; Grinberg, A; Deng, C; Wess, J.
Journal of Clinical Investigation, Vol. 106, No. 11, 12.2000, p. 1361-71.

Immunoelectron microscopic localization of the electrogenic Na/HCO(3) cotransporter in rat and ambystoma kidney.

Maunsbach, A B; Vorum, H; Kwon, T H; Nielsen, Søren; Simonsen, B; Choi, I; Schmitt, B M; Boron, W F; Aalkjaer, C.
Journal of the American Society of Nephrology, Vol. 11, No. 12, 12.2000, p. 2179-89.

Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain.

Elkjaer, M; Vajda, Z; Nejsum, L N; Kwon, T; Jensen, U B; Amiry-Moghaddam, M; Frøkiaer, J; Nielsen, Søren.
Biochemical and Biophysical Research Communications, Vol. 276, No. 3, 05.10.2000, p. 1118-28.

Immunolocalization of electroneutral Na-HCO(3)(-) cotransporter in rat kidney.

Vorum, H; Kwon, T H; Fulton, C; Simonsen, B; Choi, I; Boron, W; Maunsbach, A B; Nielsen, Søren; Aalkjaer, C.
A J P: Renal Physiology (Online), Vol. 279, No. 5, 11.2000, p. F901-9.

Immunolocalization of NBC3 and NHE3 in the rat epididymis: colocalization of NBC3 and the vacuolar H+-ATPase.

Pushkin, A; Clark, I; Kwon, T H; Nielsen, Søren; Kurtz, I.
Journal of Andrology, Vol. 21, No. 5, 07.09.2000, p. 708-20.

Key Roles of Renal Aquaporins in Water Balance and Water-Balance Disorders.

Nielsen, Søren; Kwon, Tae-Hwan; Frøkiaer, Jørgen; Knepper, Mark A.
News in physiological sciences: an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, Vol. 15, 06.2000, p. 136-143.

Localization of aquaporin-7 in rat and mouse kidney using RT-PCR, immunoblotting, and immunocytochemistry.

Nejsum, L N; Elkjaer, M; Hager, H; Frokiaer, J; Kwon, T H; Nielsen, Søren.
Biochemical and Biophysical Research Communications, Vol. 277, No. 1, 14.10.2000, p. 164-70.

Osmotically relevant membrane signaling complex: association between HB-EGF, beta(1)-integrin, and CD9 in mTAL.

Sheikh-Hamad, D; Youker, K; Truong, L D; Nielsen, Søren; Entman, M L.
American Journal of Physiology: Cell Physiology, Vol. 279, No. 1, 07.2000, p. C136-46.

Regulated exocytosis in immune function: are SNARE-proteins involved?

Shukla, A; Berglund, L; Nielsen, L P; Nielsen, Søren; Hoffmann, H J; Dahl, R.
Respiratory Medicine, Vol. 94, No. 1, 01.2000, p. 10-17.

Regulation of AQP6 mRNA and protein expression in rats in response to altered acid-base or water balance.

Promeneur, D; Kwon, T H; Yasui, M; Kim, G H; Frøkiaer, J; Knepper, M A; Agre, P; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 279, No. 6, 12.2000, p. F1014-26.
Renal water handling in rats with decompensated liver cirrhosis.
Jonassen, T E; Christensen, S; Kwon, T H; Langhoff, S; Salling, N; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 279, No. 6, 12.2000, p. F1101-9.

The alpha(1G)-subunit of a voltage-dependent Ca(2+) channel is localized in rat distal nephron and collecting duct.

Andreasen, D; Jensen, B L; Hansen, P B; Kwon, T H; Nielsen, Søren; Skøtt, O.
A J P: Renal Physiology (Online), Vol. 279, No. 6, 12.2000, p. F997-1005.

Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats.

Promeneur, D; Kwon, T H; Frøkiaer, J; Knepper, M A; Nielsen, Søren.
A J P: Renal Physiology (Online), Vol. 279, No. 2, 08.2000, p. F370-82.
1999

Altered expression of Na transporters NHE-3, NaPi-II, Na-K-ATPase, BSC-1, and TSC in CRF rat kidneys.

Kwon, T H; Frøkiaer, J; Fernández-Llama, P; Maunsbach, A B; Knepper, M A; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 277, No. 2 Pt 2, 08.1999, p. F257-70.

Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia.

Yasui, M; Kwon, T H; Knepper, M A; Nielsen, Søren; Agre, P.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 10, 11.05.1999, p. 5808-13.

Arginine vasopressin stimulates phosphorylation of aquaporin-2 in rat renal tissue.

Nishimoto, G; Zelenina, M; Li, D; Yasui, M; Aperia, A; Nielsen, Søren; Nairn, A C.
American Journal of Physiology (Consolidated), Vol. 276, No. 2 Pt 2, 02.1999, p. F254-9.

Cellular and molecular biology of the aquaporin water channels.

Borgnia, M; Nielsen, Søren; Engel, A; Agre, P.
Annual Review of Biochemistry, Vol. 68, 1999, p. 425-58.

Decreased abundance of collecting duct aquaporins in post-ischemic renal failure in rats.

Fernández-Llama, P; Andrews, P; Turner, R; Saggi, S; Dimari, J; Kwon, T H; Nielsen, Søren; Safirstein, R; Knepper, M A.
Journal of the American Society of Nephrology, Vol. 10, No. 8, 08.1999, p. 1658-68.

Developmental expression of aquaporin 1 in the rat renal vasculature.

Kim, J; Kim, W Y; Han, K H; Knepper, M A; Nielsen, Søren; Madsen, K M.
American Journal of Physiology (Consolidated), Vol. 276, No. 4 Pt 2, 04.1999, p. F498-509.

Heterotetrameric composition of aquaporin-4 water channels.

Neely, J D; Christensen, B M; Nielsen, Søren; Agre, P.
Biochemistry, Vol. 38, No. 34, 24.08.1999, p. 11156-63.

Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains.

Nagelhus, E A; Horio, Y; Inanobe, A; Fujita, A; Haug, F M; Nielsen, Søren; Kurachi, Y; Ottersen, O P.
Glia, Vol. 26, No. 1, 03.1999, p. 47-54.

Long-term regulation of aquaporins in the kidney.

Marples, D; Frøkiaer, J; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 276, No. 3 Pt 2, 03.1999, p. F331-9.

Low aquaporin-2 levels in polyuric DI +/+ severe mice with constitutively high cAMP-phosphodiesterase activity.

Frøkiaer, J; Marples, D; Valtin, H; Morris, J F; Knepper, M A; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 276, No. 2 Pt 2, 02.1999, p. F179-90.

Mechanisms of impaired urinary concentrating ability in adult rats treated neonatally with enalapril.

Guron, G; Nilsson, A; Nitescu, N; Nielsen, Søren; Sundelin, B; Frøkiaer, J; Friberg, P.
Acta Physiologica Scandinavica, Vol. 165, No. 1, 01.1999, p. 103-12.

Ontogeny of water transport in rat brain: postnatal expression of the aquaporin-4 water channel.

Wen, H; Nagelhus, E A; Amiry-Moghaddam, M; Agre, P; Ottersen, O P; Nielsen, Søren.
European Journal of Neuroscience, Vol. 11, No. 3, 03.1999, p. 935-45.

Physiology and pathophysiology of renal aquaporins.

Nielsen, Søren; Kwon, T H; Christensen, B M; Promeneur, D; Frøkiaer, J; Marples, D.
Journal of the American Society of Nephrology, Vol. 10, No. 3, 03.1999, p. 647-63.

Rapid gating and anion permeability of an intracellular aquaporin.

Yasui, M; Hazama, A; Kwon, T H; Nielsen, Søren; Guggino, W B; Agre, P.
Nature Genetics, Vol. 402, No. 6758, 11.11.1999, p. 184-7.

Reduced abundance of aquaporins in rats with bilateral ischemia-induced acute renal failure: prevention by alpha-MSH.

Kwon, T H; Frøkiaer, J; Fernández-Llama, P; Knepper, M A; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 277, No. 3 Pt 2, 09.1999, p. F413-27.

Urinary excretion of aquaporin-2 in rat is mediated by a vasopressin-dependent apical pathway.

Wen, H; Frokiaer, J; Kwon, T H; Nielsen, Søren.
Journal of the American Society of Nephrology, Vol. 10, No. 7, 07.1999, p. 1416-29.
1998

Acute effects of vasopressin V2-receptor antagonist on kidney AQP2 expression and subcellular distribution.

Christensen, B M; Marples, D; Jensen, U B; Frokiaer, J; Sheikh-Hamad, D; Knepper, M; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 275, No. 2 Pt 2, 08.1998, p. F285-97.

Aquaporin-1 and endothelial nitric oxide synthase expression in capillary endothelia of human peritoneum.

Devuyst, O; Nielsen, Søren; Cosyns, J P; Smith, B L; Agre, P; Squifflet, J P; Pouthier, D; Goffin, E.
American Journal of Physiology (Consolidated), Vol. 275, No. 1 Pt 2, 07.1998, p. H234-42.

Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes.

Nagelhus, E A; Veruki, M L; Torp, R; Haug, F M; Laake, J H; Nielsen, Søren; Agre, P; Ottersen, O P.
Journal of Neuroscience, Vol. 18, No. 7, 01.04.1998, p. 2506-19.

Aquaporins in complex tissues: distribution of aquaporins 1-5 in human and rat eye.

Hamann, S; Zeuthen, T; La Cour, M; Nagelhus, E A; Ottersen, O P; Agre, P; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 274, No. 5 Pt 1, 05.1998, p. C1332-45.

Concentrating defect in experimental nephrotic syndrone: altered expression of aquaporins and thick ascending limb Na+ transporters.

Fernández-Llama, P; Andrews, P; Ecelbarger, C A; Nielsen, Søren; Knepper, M.
Kidney International, Vol. 54, No. 1, 07.1998, p. 170-9.

Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats.

Earm, J H; Christensen, B M; Frøkiaer, J; Marples, D; Han, J S; Knepper, M A; Nielsen, Søren.
Journal of the American Society of Nephrology, Vol. 9, No. 12, 12.1998, p. 2181-93.

Decreased vasopressin-mediated renal water reabsorption in rats with compensated liver cirrhosis.

Jonassen, T E; Nielsen, Søren; Christensen, S; Petersen, J S.
American Journal of Physiology (Consolidated), Vol. 275, No. 2 Pt 2, 08.1998, p. F216-25.

Dehydration reverses vasopressin antagonist-induced diuresis and aquaporin-2 downregulation in rats.

Marples, D; Christensen, B M; Frokiaer, J; Knepper, M A; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 275, No. 3 Pt 2, 09.1998, p. F400-9.

Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord.

Rash, J E; Yasumura, T; Hudson, C S; Agre, P; Nielsen, Søren.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, No. 20, 29.09.1998, p. 11981-6.

Disordered water channel expression and distribution in acquired nephrogenic diabetes insipidus.

Marples, D; Frøkiaer, J; Knepper, M A; Nielsen, Søren.
Proceedings of the Association of American Physicians, Vol. 110, No. 5, 02.10.1998, p. 401-6.

Dynein and dynactin colocalize with AQP2 water channels in intracellular vesicles from kidney collecting duct.

Marples, D; Schroer, T A; Ahrens, N; Taylor, A; Knepper, M A; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 274, No. 2 Pt 2, 02.1998, p. F384-94.

Immunocytochemical localization of aquaporin 1 in the rat retina.

Kim, I B; Oh, S J; Nielsen, Søren; Chun, M H.
Neuroscience Letters, Vol. 244, No. 1, 06.03.1998, p. 52-4.

Impaired aquaporin and urea transporter expression in rats with adriamycin-induced nephrotic syndrome.

Fernández-Llama, P; Andrews, P; Nielsen, Søren; Ecelbarger, C A; Knepper, M A.
Kidney International, Vol. 53, No. 5, 05.1998, p. 1244-53.

Mechanism of antidiuresis caused by bendroflumethiazide in conscious rats with diabetes insipidus.

Grønbeck, L; Marples, D; Nielsen, Søren; Christensen, S.
British Journal of Pharmacology, Vol. 123, No. 4, 02.1998, p. 737-45.

Pathophysiology of aquaporin-2 in water balance disorders.

Frøkiaer, J; Marples, D; Knepper, M A; Nielsen, Søren.
The American Journal of Medicine, Vol. 316, No. 5, 11.1998, p. 291-9.

Reduced AQP1, -2, and -3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass.

Kwon, T H; Frøkiaer, J; Knepper, M A; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 275, No. 5 Pt 2, 11.1998, p. F724-41.

Renal aquaporins: key roles in water balance and water balance disorders.

Nielsen, Søren; Frøkiær, J; Knepper, M A.
Current opinion in nephrology and hypertension, Vol. 7, No. 5, 09.1998, p. 509-16.

Select types of supporting cell in the inner ear express aquaporin-4 water channel protein.

Takumi, Y; Nagelhus, E A; Eidet, J; Matsubara, A; Usami, S; Shinkawa, H; Nielsen, Søren; Ottersen, O P.
European Journal of Neuroscience, Vol. 10, No. 12, 12.1998, p. 3584-95.

SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles.

Inoue, T; Nielsen, Søren; Mandon, B; Terris, J; Kishore, B K; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 275, No. 5 Pt 2, 11.1998, p. F752-60.

Studies of renal aquaporin-2 expression during renal escape from vasopressin-induced antidiuresis.

Verbalis, J G; Murase, T; Ecelbarger, C A; Nielsen, Søren; Knepper, M A.
Advances in Experimental Medicine and Biology, Vol. 449, 1998, p. 395-406.

Ultrastructural localization of Na-K-2Cl cotransporter in thick ascending limb and macula densa of rat kidney.

Nielsen, Søren; Maunsbach, A B; Ecelbarger, C A; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 275, No. 6 Pt 2, 12.1998, p. F885-93.
1997

Apical and basolateral expression of aquaporin-1 in transfected MDCK and LLC-PK cells and functional evaluation of their transcellular osmotic water permeabilities.

Deen, P M; Nielsen, Søren; Bindels, R J; van Os, C H.
Pflügers Archiv – European Journal of Physiology, Vol. 433, No. 6, 04.1997, p. 780-7.

Aquaporin-1 water channel expression in human kidney.

Maunsbach, A B; Marples, D; Chin, E; Ning, G; Bondy, C; Agre, P; Nielsen, Søren.
Journal of the American Society of Nephrology, Vol. 8, No. 1, 01.1997, p. 1-14.

Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat.

King, L S; Nielsen, Søren; Agre, P.
American Journal of Physiology (Consolidated), Vol. 273, No. 5 Pt 1, 11.1997, p. C1541-8.

Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat.

Nielsen, Søren; King, L S; Christensen, B M; Agre, P.
American Journal of Physiology (Consolidated), Vol. 273, No. 5 Pt 1, 11.1997, p. C1549-61.

Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct.

Nielsen, Søren; Terris, J; Andersen, D; Ecelbarger, C; Frokiaer, J; Jonassen, T; Marples, D; Knepper, M A; Petersen, J S.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 10, 13.05.1997, p. 5450-5.

Detection of Duffy antigen in the plasma membranes and caveolae of vascular endothelial and epithelial cells of nonerythroid organs.

Chaudhuri, A; Nielsen, Søren; Elkjaer, M L; Zbrzezna, V; Fang, F; Pogo, A O.
Blood, Vol. 89, No. 2, 15.01.1997, p. 701-12.

Do aquaporins have a role in nocturnal enuresis?

Frøkiaer, J; Nielsen, Søren.
Scandinavian Journal of Urology and Nephrology. Supplement, Vol. 183, 1997, p. 31-2.

Downregulation of aquaporin-2 parallels changes in renal water excretion in unilateral ureteral obstruction.

Frøkiaer, J; Christensen, B M; Marples, D; Djurhuus, J C; Jensen, U B; Knepper, M A; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 273, No. 2 Pt 2, 08.1997, p. F213-23.

Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta.

Pallone, T L; Kishore, B K; Nielsen, Søren; Agre, P; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 272, No. 5 Pt 2, 05.1997, p. F587-96.

Expression of syntaxins in rat kidney.

Mandon, B; Nielsen, Søren; Kishore, B K; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 273, No. 5 Pt 2, 11.1997, p. F718-30.

Internalization and apical-to-basolateral transport of folate in rat kidney proximal tubule.

Birn, H; Nielsen, Søren; Christensen, E I.
American Journal of Physiology (Consolidated), Vol. 272, No. 1 Pt 2, 01.1997, p. F70-8.

Internalization and recycling of glycoprotein 280 in epithelial cells of yolk sac.

Le Panse, S; Ayani, E; Nielsen, Søren; Ronco, P; Verroust, P; Christensen, E I.
Journal of Cell Biology, Vol. 72, No. 3, 03.1997, p. 257-67.

Perinatal changes in expression of aquaporin-4 and other water and ion transporters in rat lung.

Yasui, M; Serlachius, E; Löfgren, M; Belusa, R; Nielsen, Søren; Aperia, A.
Journal of Physiology, Vol. 505 ( Pt 1), 15.11.1997, p. 3-11.

Role of aquaporins in water balance disorders.

Knepper, M A; Verbalis, J G; Nielsen, Søren.
Current opinion in nephrology and hypertension, Vol. 6, No. 4, 07.1997, p. 367-71.

Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat.
Ecelbarger, C A; Nielsen, Søren; Olson, B R; Murase, T; Baker, E A; Knepper, M A; Verbalis, J G.

Journal of Clinical Investigation, Vol. 99, No. 8, 15.04.1997, p. 1852-63.

Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain.

Nielsen, Søren; Nagelhus, E A; Amiry-Moghaddam, M; Bourque, C; Agre, P; Ottersen, O P.
Journal of Neuroscience, Vol. 17, No. 1, 01.01.1997, p. 171-80.

The 17 kDa band identified by multiple anti-aquaporin 2 antisera in rat kidney medulla is a histone.

Jo, I; Nielsen, Søren; Harris, H W.
BBA Gene Regulatory Mechanisms, Vol. 1324, No. 1, 21.02.1997, p. 91-101.
1996

Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat.

King, L S; Nielsen, Søren; Agre, P.
Journal of Clinical Investigation, Vol. 97, No. 10, 15.05.1996, p. 2183-91.

Aquaporin water channels in the kidney: localization and regulation.
Nielsen, Søren.

Peritoneal Dialysis International, Vol. 16 Suppl 1, 1996, p. S25-7.

Bilateral ureteral obstruction downregulates expression of vasopressin-sensitive AQP-2 water channel in rat kidney.

Frøkiaer, J; Marples, D; Knepper, M A; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 270, No. 4 Pt 2, 04.1996, p. F657-68.

Cellular and subcellular localization of the vasopressin- regulated urea transporter in rat kidney.

Nielsen, Søren; Terris, J; Smith, C P; Hediger, M A; Ecelbarger, C A; Knepper, M A.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 11, 28.05.1996, p. 5495-500.

Development of urinary concentrating capacity: role of aquaporin-2.

Yasui, M; Marples, D; Belusa, R; Eklöf, A C; Celsi, G; Nielsen, Søren; Aperia, A.
American Journal of Physiology (Consolidated), Vol. 271, No. 2 Pt 2, 08.1996, p. F461-8.

Human blood eosinophils produce and secrete interleukin 4.

Bjerke, T; Gaustadnes, M; Nielsen, Søren; Nielsen, L P; Schiøtz, P O; Rüdiger, N; Reimert, C M; Dahl, R; Christensen, EI; Poulsen, L K.
Respiratory Medicine, Vol. 90, No. 5, 05.1996, p. 271-7.

Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex.

Marples, D; Frøkiaer, J; Dørup, J; Knepper, M A; Nielsen, Søren.
Journal of Clinical Investigation, Vol. 97, No. 8, 15.04.1996, p. 1960-8.

In vivo inhibition of transcellular water channels (aquaporin-1) during acute peritoneal dialysis in rats.

Carlsson, O; Nielsen, Søren; Rasheid, E.R.; Rippe, B.
American Journal of Physiology (Consolidated), Vol. 271, No. 6 Pt 2, 12.1996, p. H2254-62.

Localization and regulation of the rat renal Na(+)-K(+)-2Cl- cotransporter, BSC-1.

Ecelbarger, C A; Terris, J; Hoyer, J R; Nielsen, Søren; Wade, J B; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 271, No. 3 Pt 2, 09.1996, p. F619-28.

Long-term regulation of four renal aquaporins in rats.

Terris, J; Ecelbarger, C A; Nielsen, Søren; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 271, No. 2 Pt 2, 08.1996, p. F414-22.

Renal aquaporins.

Knepper, M A; Wade, J B; Terris, J; Ecelbarger, C A; Marples, D; Mandon, B; Chou, C L; Kishore, B K; Nielsen, Søren.
Kidney International, Vol. 49, No. 6, 06.1996, p. 1712-7.

Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking.

Mandon, B; Chou, C L; Nielsen, Søren; Knepper, M A.
Journal of Clinical Investigation, Vol. 98, No. 4, 15.08.1996, p. 906-13.

The aquaporin family of water channels in kidney.

Agre, P; Nielsen, Søren.
Nephrologie, Vol. 17, No. 7, 1996, p. 409-15.

The aquaporin family of water channels in kidney: an update on physiology and pathophysiology of aquaporin-2.

Nielsen, Søren; Marples, D; Frøkiaer, J; Knepper, M; Agre, P.
Kidney International, Vol. 49, No. 6, 06.1996, p. 1718-23.

A flat-coil NMR probe with hydration control of oriented phospholipid bilayer samples.

Nielsen, N C; Daugaard, P; Langer, V; Thomsen, J K; Nielsen, Søren; Sørensen, O W; Jakobsen, H J.
Journal of Biomolecular N M R, Vol. 5, No. 3, 04.1995, p. 311-4.

Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney.

Nielsen, Søren; Pallone, T L; Smith, B L; Christensen, E I; Agre, P; Maunsbach, A B.
American Journal of Physiology (Consolidated), Vol. 268, No. 6 Pt 2, 06.1995, p. F1023-37.

Aquaporin-3 water channel localization and regulation in rat kidney.

Ecelbarger, C A; Terris, J; Frindt, G; Echevarria, M; Marples, D; Nielsen, Søren; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 269, No. 5 Pt 2, 11.1995, p. F663-72.

Aquaporin water channels: unanswered questions and unresolved controversies.

Agre, P; Brown, D; Nielsen, Søren.
Current Opinion in Cell Biology, Vol. 7, No. 4, 08.1995, p. 472-83.

Diffusive transport of solute in the rat medullary microcirculation.

Pallone, T L; Nielsen, Søren; Silldorff, E P; Yang, S.
American Journal of Physiology (Consolidated), Vol. 269, No. 1 Pt 2, 07.1995, p. F55-63.

Distribution of aquaporin-4 water channel expression within rat kidney.

Terris, J; Ecelbarger, C A; Marples, D; Knepper, M A; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 269, No. 6 Pt 2, 12.1995, p. F775-85.

Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of Aquaporin-1 and gp330 in proximal tubule cells.

Elkjaer, M L; Birn, H.; Agre, P; Christensen, E I; Nielsen, Søren.
Journal of Cell Biology, Vol. 67, No. 1, 05.1995, p. 57-72.

Expression of VAMP-2-like protein in kidney collecting duct intracellular vesicles. Colocalization with Aquaporin-2 water channels.

Nielsen, Søren; Marples, D; Birn, H.; Mohtashami, M; Dalby, N O; Trimble, M; Knepper, M A.
Journal of Clinical Investigation, Vol. 96, No. 4, 10.1995, p. 1834-44.

Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla.

Marples, D; Christensen, S; Christensen, E I; Ottosen, P D; Nielsen, Søren.
Journal of Clinical Investigation, Vol. 95, No. 4, 04.1995, p. 1838-45.

Oxytocin as an antidiuretic hormone. I. Concentration dependence of action.

Chou, C.L.; DiGiovanni, S R; Mejia, R; Nielsen, Søren; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 269, No. 1 Pt 2, 07.1995, p. F70-7.

Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct.

Marples, D; Knepper, M A; Christensen, E I; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 269, No. 3 Pt 1, 09.1995, p. C655-64.

Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules.

Christensen, E I; Nielsen, Søren; Moestrup, S K; Borre, C; Maunsbach, A B; de Heer, E; Ronco, P; Hammond, T G; Verroust, P.
Journal of Cell Biology, Vol. 66, No. 4, 04.1995, p. 349-64.

The aquaporin family of water channels in kidney.

Nielsen, Søren; Agre, P.
Kidney International, Vol. 48, No. 4, 10.1995, p. 1057-68.

The levels of ubiquitinated histone H2A are highly upregulated in transformed human cells: partial colocalization of uH2A clusters and PCNA/cyclin foci in a fraction of cells in S-phase.

Vassilev, A P; Rasmussen, H H; Christensen, E I; Nielsen, Søren; Celis, J E.
Journal of Cell Science, Vol. 108 ( Pt 3), 03.1995, p. 1205-15.

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.

Nielsen, Søren; Chou, C.L.; Marples, D; Christensen, E I; Kishore, B K; Knepper, M A.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 4, 14.02.1995, p. 1013-7.

Binding and endocytosis of proteins mediated by epithelial gp330.

Moestrup, S K; Christensen, E I; Nielsen, Søren; Jørgensen, K E; Bjørn, S E; Røigaard, H; Gliemann, J.
Annals of the New York Academy of Sciences, Vol. 737, 10.09.1994, p. 124-37.

Endocytosis in renal proximal tubules. Experimental electron microscopical studies of protein absorption and membrane traffic in isolated, in vitro perfused proximal tubules.

Nielsen, Søren.
Danish Medical Bulletin (Print), Vol. 41, No. 3, 06.1994, p. 243-63.

Examination of rat salivary glands for the presence of the aquaporin CHIP.

Li, J; Nielsen, Søren; Dai, Y; Lazowski, K W; Christensen, E I; Tabak, L A; Baum, B J.
Pflügers Archiv – European Journal of Physiology, Vol. 428, No. 5-6, 10.1994, p. 455-60.

Long-term regulation of collecting duct water permeability: freeze-fracture analysis of isolated perfused tubules.

Wade, J B; Nielsen, Søren; Coleman, R A; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 266, No. 5 Pt 2, 05.1994, p. F723-30.

Mechanism of vasopressin action in the renal collecting duct.

Knepper, M A; Nielsen, Søren; Chou, C.L.; DiGiovanni, S R.
Seminars in Nephrology, Vol. 14, No. 4, 07.1994, p. 302-21.

Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat.

DiGiovanni, S R; Nielsen, Søren; Christensen, E I; Knepper, M A.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 19, 13.09.1994, p. 8984-8.

Ultrastructure, pharmacologic inhibition, and transport selectivity of aquaporin channel-forming integral protein in proteoliposomes.

Zeidel, M L; Nielsen, Søren; Smith, B L; Ambudkar, S V; Maunsbach, A B; Agre, P.
Biochemistry, Vol. 33, No. 6, 15.02.1994, p. 1606-15.

Aquaporin CHIP: the archetypal molecular water channel.

Agre, P; Preston, G M; Smith, B L; Jung, J S; Raina, S; Moon, C; Guggino, Wm B; Nielsen, Søren.
American Journal of Physiology (Consolidated), Vol. 265, No. 4 Pt 2, 10.1993, p. F463-76.

Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney.

Nielsen, Søren; DiGiovanni, S R; Christensen, E I; Knepper, M A; Harris, H W.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 24, 15.12.1993, p. 11663-7.

Concurrent expression of erythroid and renal aquaporin CHIP and appearance of water channel activity in perinatal rats.

Smith, B L; Baumgarten, R; Nielsen, Søren; Raben, D; Zeidel, M L; Agre, P.
Journal of Clinical Investigation, Vol. 92, No. 4, 10.1993, p. 2035-41.

Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.

Nielsen, Søren; Smith, B L; Christensen, E I; Agre, P.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, No. 15, 01.08.1993, p. 7275-9.

Structural-functional correlation in chinchilla long loop of Henle thin limbs: a novel papillary subsegment.

Chou, C.L.; Nielsen, Søren; Knepper, M A.
American Journal of Physiology (Consolidated), Vol. 265, No. 6 Pt 2, 12.1993, p. F863-74.

Transcellular transport of ferritin in rabbit renal proximal tubules.

Cui, S; Nielsen, Søren; Bjerke, T; Christensen, E I.
Journal of Nephrology, Vol. 1, No. 5, 01.09.1993, p. 309-18.