John D. Vestergaard Nieland, Ph.D., Associate Professor
COO

Email: jdn@2apharma.com

John Nieland brings broad management experience, an in-depth research background in immunology and an expertise in the development of biopharmaceuticals and coordination and development of clinical trials. He worked as head of immunology and later director of research at Medigene AG, where has was involved in the development of the AAV-HPV vaccine and held the position of vice president preclinical research at Borean Pharma. John initiated and collaborated on numerous projects, has published more than 30 articles and is the inventor of 15 patents, including several on the AAV vaccine platform. In addition to his scientific experience, John has extensive business experience and is the founder/co-founder of three biotech companies.

Publications

Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with etomoxir or interferon-β.

Mørkholt, Anne Skøttrup; Kastaniegaard, Kenneth; Trabjerg, Michael Sloth; Gopalasingam, Gopana; Niganze, Wanda; Larsen, Agnete; Stensballe, Allan; Nielsen, Søren; Nieland, John Dirk.
Scientific Reports, Vol. 8, No. 1, 7092, 04.05.2018.

Blocking of carnitine palmitoyl transferase 1 potently reduces stress-induced depression in rat highlighting a pivotal role of lipid metabolism.

Mørkholt, Anne Skøttrup; Wiborg, Ove; Nieland, Jette G. K.; Nielsen, Søren; Nieland, John Dirk.
Scientific Reports, Vol. 7, 2158, 19.05.2017.

Characterization of human autoantibody response to brain proteins in multiple sclerosis patients.

Mørkholt, Anne Skøttrup; Kastaniegaard, Kenneth; Stensballe, Allan; Nielsen, Søren; Nieland, John Dirk.
International Journal of MS Care, Vol. 19, No. Suppl. 1, (NP02), 2017, p. 54.

Comparison of Etomoxir, a lipid metabolism blocker, and interferon-beta treatment on antibody recognition of brain proteins in Multiple Sclerosis.

Mørkholt, Anne Skøttrup; Kastaniegaard, Kenneth; Trabjerg, Michael Sloth; Gopalasingam, Gopana; Niganze, Wanda; Oklinski, Michal Krystian; Larsen, Agnete; Nieland, Jette G. K.; Stensballe, Allan; Nielsen, Søren; Nieland, John Dirk; Mørkholt, Anne Skøttrup.
2017. Abstract from Annual Meeting of the Consortium of Multiple Sclerosis Centers, CMSC, New Orleans, LA, United States.

Comparison of etomoxir, a lipid metabolism blocker, and interferon beta treatment on antibody recognition of brain proteins in multiple sclerosis.

Mørkholt, Anne Skøttrup; Kastaniegaard, Kenneth; Trabjerg, Michael Sloth; Gopalasingam, Gopana; Niganze, Wanda; Oklinski, Michal Krystian; Larsen, Agnete; Nieland, Jette G. K.; Stensballe, Allan; Nielsen, Søren; Nieland, John Dirk.
International Journal of MS Care, Vol. 19, No. Suppl. 1, (NP01), 2017, p. 54.

Comparison of Etomoxir, a lipid metabolism blocker, and interferon-β treatment on antibody recognition of brain proteins in Multiple Sclerosis.

Mørkholt, Anne Skøttrup; Kastaniegaard, Kenneth; Trabjerg, Michael Sloth; Niganze, Wanda; Gopalasingam, Gopana; Larsen, Agnete; Stensballe, Allan; Nielsen, Søren; Nieland, John Dirk.
2017. Poster presented at Annual Meeting of the Consortium of Multiple Sclerosis Centers, CMSC, New Orleans, LA, United States.

Digging deeper into MS pathology : Is lipid metabolism at the root?

Ford, Corey C.; Nieland, John Dirk.
The Science of MS Management. The Consortium of Multiple Sclerosis Centers, CMSC, 2017.
Research output: Book chapter › Education › peer-review

Modifications like citrulination and MDA adducts, lipidation, and the immune system : A menage à trois gone wrong in multiple sclerosis.

Kastaniegaard, Kenneth; Nieland, John Dirk; Mørkholt, Anne Skøttrup; Stensballe, Allan; Nielsen, Søren.
International Journal of MS Care, Vol. 19, No. Suppl. 1, NP05, 2017, p. 55-56.

The effect of CPT1a inhibition in ischemic CNS injury : Studies in a murine model of permanent middle cerebral artery occlusion (MCAO).

Poulsen, Kristoffer Bødkergaard; Flaeng, S. B.; Lambertsen, K. L.; Nieland, John Dirk; Nielsen, Søren; Larsen, A.
Kongres for Medicinsk Studenterforskning, Abstracts, 16.-19. marts 2017, Nyborg, Danmark. Selskab for Medicinsk Studenterforskning, 2017. p. 66.

Aquaporins in the spinal cord.

Oklinski, Michael Krystian; Skowronski, Mariusz T.; Skowronska, Agnieszka; Rützler, Michael; Jensen, Kirsten Nørgaard; Nieland, John D.; Kwon, Tae-Hwan; Nielsen, Søren.
International Journal of Molecular Sciences , Vol. 17, No. 12, 2050, 2016.

Assessing the Role of Citrullination and Lipid Interaction with Myelin Basic Protein in Multiple Sclerosis Etiology.

Kastaniegaard, Kenneth; Bennike, Tue Bjerg; Nielsen, Søren; Stensballe, Allan; Nieland, John Dirk.
2016. Abstract from Consortium of Multiple Sclerosis Centers (CMSC) 2016 Annual Meeting, National Harbor, MD, United States.

Blocking the Lipid Metabolism As a New Treatment Strategy for Multiple Sclerosis.

Mørkholt, Anne Skøttrup; Nielsen, Søren; Nieland, John Dirk.
2016. Abstract from Annual Meeting of the Consortium of Multiple Sclerosis Centers, CMSC, National Harbor, MD, United States.

Blocking the lipid metabolism as a new treatment strategy for multiple sclerosis.

Mørkholt, Anne Skøttrup; Larsen, Agnete; Nieland, Jette G. K.; Issazadeh, Shohreh; Nielsen, Søren; Nieland, John Dirk.
2016. Poster presented at Annual Meeting of the Consortium of Multiple Sclerosis Centers, CMSC, National Harbor, MD, United States.

Highly effective treatment of multiple sclerosis by blocking the lipid metabolism.

Mørkholt, Anne Skøttrup; Larsen, Agnete; Issazadeh, Shohreh; Nieland, Jette G. K.; Nielsen, Søren; Nieland, John Dirk.
2016. Abstract from 32nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis, ECTRIMS, London, United Kingdom.

Proteomics-driven design of endothelial stress-based protein array for disease prognostics : applied to plasma and cerebrospinal fluid.

Kastaniegaard, Kenneth; Jørgensen, Malene Møller; Bæk, Rikke ; Sejrbæk, Tobias; Wiwie, C.; Baumbach, J.; Zachar, Vladimir; Moos, Torben; Nielsen, Søren; Nieland, John Dirk; Cotton, F.; Guttmann, C.; Illes, Z.; Stensballe, Allan.
Journal of Extracellular Vesicles, Vol. 5, No. Suppl. 1, OW2.2, 2016, p. 4.

Teaching portfolio.

Nieland, John Dirk.

CPT1a mutation leads the way for new medication for the treatment of multiple sclerosis.

Nieland, John Dirk; Nieland, Jette G. K.; Mørkholt, Anne Skøttrup; Bolther, Luise; Nielsen, Søren.
Multiple Sclerosis Journal, Vol. 21, No. 11 (Suppl.), 2015, p. 786-787, No. P1497.